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Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study.

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Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Canonica, Giorgio Walter Fumagalli, Federica Guerra, Laura Baiardini, Ilaria Compalati, Enrico Rogkakou, Anthi Massacane, Pierangela Gamalero, Cinzia Riccio, Anna Maria Scordamaglia, Antonio Passalacqua, Giovanni
Organization	Global Allergy and Asthma European Network
Description	Country affiliation: Italy Author Affiliation: Canonica GW ( University of Genoa, Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa, Italy. canonica@unige.it)
Abstract	BACKGROUND: Allergic rhinitis is a high-prevalence disease that affects quality of life (QOL), sleep quality and productivity of patients. According to the ARIA initiative, it is classified as intermittent and persistent, the latter being the most troublesome. METHODS: The aim of this randomized, open-label, 6-month, pilot study was to determine whether levocetirizine 5 mg administered continuously once daily in the morning was better than levocetirizine 5 mg on-demand in symptomatic subjects with persistent allergic rhinitis. Total and individual symptom scores were recorded in a diary card throughout the study. QOL, quality of sleep, nasal cytology, rate of drug intake, and safety were also assessed at pre-defined time-points. RESULTS: In all, adult patients (31 in each group) were enrolled, of whom 22 dropped out. Both treatment regimens considerably decreased the total and individual symptoms scores from baseline and achieved similar levels up to week 14. Continuous treatment was generally better than on-demand from week 15 onwards, reaching statistical significance from weeks 17 to 21 (from week 19 to 21 for nasal pruritus). Both regimens substantially improved QOL and sleep quality. Both treatments were well tolerated, although the on-demand group reported more adverse events. CONCLUSION: The present open label study in 62 patients indicates that levocetirizine 5 mg reliably controls persistent rhinitis over a period of 6 months, and shows a trend to be more effective in controlling the symptoms of rhinitis, improving QOL and decreasing nasal inflammation, when administered as long-term continuous therapy rather than as on-demand therapy.
File Format	HTM / HTML
ISSN	03007995
Issue Number	10
Volume Number	24
e-ISSN	14734877
Journal	Current Medical Research and Opinion
Language	English
Publisher	Taylor & Francis
Publisher Date	2008-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Medicine Cetirizine Administration & Dosage Histamine H1 Antagonists, Non-sedating Rhinitis, Allergic, Perennial Drug Therapy Adult Aged Female Humans Inflammation Diet Therapy Pathology Male Middle Aged Pilot Projects Quality Of Life Time Factors Clinical Trial, Phase Iv Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine

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