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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gurley, Kay E. Moser, Russell D. Kemp, Christopher J. |
| Description | Author Affiliation: Gurley KE ( Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.); Moser RD ( Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.); Kemp CJ ( Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.) |
| Abstract | Since the groundbreaking studies in the middle part of the last century showing liver cancer in rodents exposed to aromatic amines, the liver has been widely used as a model target organ of chemical carcinogenesis. This protocol describes a method for inducing liver tumors by injecting mice with the widely used alkylating agents N-ethyl-N-nitrosourea (ENU) and N-nitrosodiethylamine (DEN). ENU does not require metabolic activation and readily induces tumors in a number of tissues, including the lungs, stomach, and ovaries, as well as inducing lymphomas. Mice injected with DEN can also develop other tumors, including those of the gastrointestinal tract, skin, lungs, and lymphocytes, but because DEN is metabolized in the liver, it is most effective at inducing liver tumors. |
| File Format | HTM / HTML |
| ISSN | 19403402 |
| Issue Number | 10 |
| Volume Number | 2015 |
| e-ISSN | 15596095 |
| Journal | Cold Spring Harbor Protocols |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2015-10-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Laboratory Techniques Carcinogens Administration & Dosage Diethylnitrosamine Ethylnitrosourea Liver Neoplasms Chemically Induced Animals Injections, Intraperitoneal Mice Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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