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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Palmisano, Nicholas J. Meléndez, Alicia |
| Description | Author Affiliation: Palmisano NJ ( Department of Biology, Queens College-CUNY, Flushing, New York 11367); Meléndez A ( Department of Biology, Queens College-CUNY, Flushing, New York 11367) |
| Abstract | Autophagy plays an active role during the early stages of embryogenesis in the nematode Caenorhabditis elegans. Although their exact function is unknown, P granules are ribonucleoprotein particles that play a role in germ cell specification. The localization of P granules is restricted to the germline precursor cells in wild-type embryos, as a result of their degradation in the somatic cell lineage. Autophagy is known to be required for the degradation of P granules, as mutations in various autophagy genes, including those encoding the adaptor SEPA-1 and the p62-like adaptor SQST-1, result in the accumulation of the P granule components PGL-1 and PGL-3 (termed PGL granules) in the somatic cells of C. elegans embryos. In this protocol, we present a methodology for using fusion reporters of SEPA-1, SQST-1, and PGL-1 that have aided in the identification of new genes for normal autophagy activity by screening for mutant animals that lack the degradation of these autophagy substrates. |
| File Format | HTM / HTML |
| ISSN | 19403402 |
| Issue Number | 1 |
| Volume Number | 2016 |
| e-ISSN | 15596095 |
| Journal | Cold Spring Harbor Protocols |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2016-01-04 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Clinical Laboratory Techniques Autophagy Physiology Caenorhabditis Elegans Cytology Embryology Embryonic Development Germ Cells Pathology Rna-binding Proteins Metabolism Animals Genetics Proteolysis Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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