NDLI: Apparent diffusion coefficient as a non-invasive predictor of treatment response and recurrence in locally advanced rectal cancer.

Please wait, while we are loading the content...

Re: Comprehensive MRA of the lower limbs including high-resolution extended-phase infra-inguinal imaging with gadobenate dimeglumine: initial experience with inter-individual comparison to the blood-pool contrast agent gadofosveset trisodium. A reply.

The MSCT and MRI findings of collecting duct carcinoma.

A radiologist's guide to small bowel and multivisceral transplantation.

Low-dose abdominal CT: comparison of low tube voltage with moderate-level iterative reconstruction and standard tube voltage, low tube current with high-level iterative reconstruction.

Contrast-enhanced MR enterography as a stand-alone tool to evaluate Crohn's disease in a paediatric population.

Adiposis dolorosa (Dercum's disease): MRI and ultrasound appearances.

Delayed gadolinium-enhanced MRI of cartilage of the ankle joint: results after autologous matrix-induced chondrogenesis (AMIC)-aided reconstruction of osteochondral lesions of the talus.

Pre-treatment with a sinus node blockade, ivabradine, before coronary CT angiography: a retrospective audit.

ECG-gated imaging of the left atrium and pulmonary veins: Intra-individual comparison of CTA and MRA.

Tail-end troubles: imaging of soft-tissue buttock tumours.

Mortality reporting in interventional radiology: experience of a pilot audit with the Scottish Audit of Surgical Mortality.

Pattern of brain metastatic disease according to HER-2 and ER receptor status in breast cancer patients.

Prostate MRI: who, when, and how? Report from a UK consensus meeting.

Apparent diffusion coefficient as a non-invasive predictor of treatment response and recurrence in locally advanced rectal cancer.

Medial joint line bone bruising at MRI complicating acute ankle inversion injury: what is its clinical significance?

Diffusion-weighted MRI of the normal adult pancreas: the effect of age on apparent diffusion coefficient values.

Use of CT in the management of anterior cruciate ligament revision surgery.

MRI of optic tract lesions: review and correlation with visual field defects.

Year: 2013 Volume: 68 Issue: 9

Year: 2013 Volume: 68 Issue: 8

Year: 2013 Volume: 68 Issue: 7

Year: 2013 Volume: 68 Issue: 6

Year: 2013 Volume: 68 Issue: 5

Year: 2013 Volume: 68 Issue: 4

Year: 2013 Volume: 68 Issue: 3

Year: 2013 Volume: 68 Issue: 2

Year: 2013 Volume: 68 Issue: 1

Year: 2012 Volume: 67

Year: 2011 Volume: 66

Year: 2010 Volume: 65

Year: 2009 Volume: 64

Year: 2008 Volume: 63

Apparent diffusion coefficient as a non-invasive predictor of treatment response and recurrence in locally advanced rectal cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Elmi, A. Hedgire, S. S. Covarrubias, D. Abtahi, S. M. Hahn, P. F. Harisinghani, M.
Description	Country affiliation: United States Author Affiliation: Elmi A ( Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. aelmi@partners.org)
Abstract	AIM: To evaluate the role of pretreatment apparent diffusion coefficient (ADC) as a predictor of treatment response and local recurrence in patients with locally advanced rectal cancer who underwent neoadjuvant therapy. MATERIALS AND METHODS: Forty-nine patients who underwent preoperative diffusion-weighted magnetic resonance imaging (MRI) followed by neoadjuvant chemoradiation and surgery were enrolled in the study. The mean tumour ADC was measured independently from multiple, non-overlapping regions of interest (ROIs) to cover the entire tumour area on a single section by two radiologists and patients were followed postoperatively for a median of 16.4 months. Diagnostic accuracy of ADC for predicting treatment response and recurrence was evaluated using the area under the receiver-operating characteristic (ROC) curve, sensitivity, specificity, and predictive values. Univariate and multivariate analyses including clinical tumour (cT) staging, carcinoembryonic antigen (CEA) level, lymph-node involvement, tumour grade, surgical margin, vascular involvement, and ADC were performed with respect to recurrence. Interobserver agreement of ADC values was assessed. RESULTS: Twenty patients showed response to neoadjuvant therapy and recurrence was noted in 17 patients. Low pretreatment ADC, MRI findings of cT4 staging, and node involvement were significantly related to poor treatment response. Sensitivity and specificity of ADC = 0.833 × 10(-3) mm(2)/s for prediction of treatment response was 75 and 48% for reader 1 and 65 and 52% for reader 2, respectively. Univariate and multivariate analyses identified pretreatment tumour ADC as the only predictive factor for recurrence. Sensitivity and specificity of ADC = 0.833 × 10(-3) mm(2)/s for prediction of recurrence was 86 and 77% for reader 1 and 80 and 69% for reader 2, respectively. Interobserver agreement for measuring ADC was good with a kappa value of 0.70. CONCLUSION: Pretreatment rectal tumour ADC values may be an early biomarker for predicting treatment response and local recurrence in patients who underwent neoadjuvant chemoradiation.
File Format	HTM / HTML
ISSN	00099260
Issue Number	10
Volume Number	68
e-ISSN	1365229X
Journal	Clinical Radiology
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Radiology Diffusion Magnetic Resonance Imaging Methods Rectal Neoplasms Pathology Therapy Chemoradiotherapy Contrast Media Female Gadolinium Dtpa Humans Lymphatic Metastasis Male Middle Aged Neoadjuvant Therapy Neoplasm Recurrence, Local Neoplasm Staging Predictive Value Of Tests Roc Curve Treatment Outcome Journal Article
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Combined T2w volumetry, DW-MRI and DCE-MRI for response assessment after neo-adjuvant chemoradiation in locally advanced rectal cancer.

Multiparametric MRI-based radiomic model for predicting lymph node metastasis after neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Apparent diffusion coefficient for lymph node characterization after chemoradiation therapy for locally advanced rectal cancer.

The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer

Diffusion-weighted imaging for evaluating lymph node eradication after neoadjuvant chemoradiation therapy in locally advanced rectal cancer.

Apparent diffusion coefficient for the prediction of tumor response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer

Neoadjuvant concurrent chemoradiotherapy in treating locally advanced rectal cancer.

Timing of surgery after neoadjuvant long-course chemoradiotherapy in the management of locally advanced rectal cancer.

A Deep Learning Model to Predict the Response to Neoadjuvant Chemoradiotherapy by the Pretreatment Apparent Diffusion Coefficient Images of Locally Advanced Rectal Cancer

Apparent diffusion coefficient as a non-invasive predictor of treatment response and recurrence in locally advanced rectal cancer.

Similar Documents

Combined T2w volumetry, DW-MRI and DCE-MRI for response assessment after neo-adjuvant chemoradiation in locally advanced rectal cancer.

Multiparametric MRI-based radiomic model for predicting lymph node metastasis after neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Apparent diffusion coefficient for lymph node characterization after chemoradiation therapy for locally advanced rectal cancer.

The apparent diffusion coefficient is a useful biomarker in predicting treatment response in patients with locally advanced rectal cancer

Diffusion-weighted imaging for evaluating lymph node eradication after neoadjuvant chemoradiation therapy in locally advanced rectal cancer.

Apparent diffusion coefficient for the prediction of tumor response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer

Neoadjuvant concurrent chemoradiotherapy in treating locally advanced rectal cancer.

Timing of surgery after neoadjuvant long-course chemoradiotherapy in the management of locally advanced rectal cancer.

A Deep Learning Model to Predict the Response to Neoadjuvant Chemoradiotherapy by the Pretreatment Apparent Diffusion Coefficient Images of Locally Advanced Rectal Cancer

Apparent diffusion coefficient as a non-invasive predictor of treatment response and recurrence in locally advanced rectal cancer.