NDLI: Combined T2w volumetry, DW-MRI and DCE-MRI for response assessment after neo-adjuvant chemoradiation in locally advanced rectal cancer.

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Combined T2w volumetry, DW-MRI and DCE-MRI for response assessment after neo-adjuvant chemoradiation in locally advanced rectal cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Intven, Martijn Monninkhof, Evelyn M. Reerink, Onne Philippens, Marielle E. P.
Description	Country affiliation: Netherlands Author Affiliation: Intven M ( a Department of Radiotherapy , University Medical Center Utrecht , Utrecht , The Netherlands.); Monninkhof EM ( b Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht , Utrecht , The Netherlands.); Reerink O ( a Department of Radiotherapy , University Medical Center Utrecht , Utrecht , The Netherlands.); Philippens ME ( a Department of Radiotherapy , University Medical Center Utrecht , Utrecht , The Netherlands.)
Abstract	BACKGROUND: To assess the value of combined T2-weighted magnetic resonance imaging (MRI) (T2w) volumetry, diffusion-weighted (DW)-MRI and dynamic contrast enhanced (DCE)-MRI for pathological response prediction after neo-adjuvant chemoradiation (CRT) in locally advanced rectal cancer (LARC). MATERIAL AND METHODS: MRI with DW-MRI and DCE-MRI sequences was performed before start of CRT and before surgery. After surgery, the tumor regression grade (TRG) was obtained based on the score by Mandard et al. Pathological complete responders (pCR, TRG 1), and pathological good responders (GR, TRG 1 + 2) were compared to non-pCR and non-GR patients, respectively. RESULTS: In total 55 patients were analyzed, six had a pCR (10.9%) and 10 a GR (18.2%). Favorable responders had a larger decrease in tumor volume and Ktrans and a larger increase in apparent diffusion coefficient (ADC) values compared to non-responders. ADC change showed the best diagnostic accuracy for pCR. For GR, the model including ADC change and volume change showed the best diagnostic performance. However, this performance was not statistically better compared to the model with ADC change alone. Inclusion of Ktrans change did not increase the diagnostic accuracy for pathological favorable response. CONCLUSIONS: This explorative study showed that ADC change is a promising diagnostic tool for pCR and GR. Volume decrease showed potential limited additional diagnostic value for GR while Ktrans change showed no additional diagnostic value for pCR and GR.
File Format	HTM / HTML
ISSN	0284186X
e-ISSN	1651226X
Journal	Acta Oncologica
Issue Number	10
Volume Number	54
Language	English
Publisher	Taylor and Francis
Publisher Date	2015-11-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Oncology Adenocarcinoma Therapy Diffusion Magnetic Resonance Imaging Rectal Neoplasms Pathology Area Under Curve Chemoradiotherapy Contrast Media Diffusion Lymphatic Metastasis Neoadjuvant Therapy Predictive Value Of Tests Prospective Studies Roc Curve Tumor Burden
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Hematology Oncology

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