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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Layer, Paul G. Klaczinski, Janine Salfelder, Anika Sperling, Laura E. Thangaraj, Gopenath Tuschl, Corina Vogel-Höpker, Astrid |
| Description | Country affiliation: Germany Author Affiliation: Layer PG ( Technische Universität Darmstadt, Entwicklungsbiologie & Neurogenetik, Darmstadt, Germany. layer@bio.tu-darmstadt.de) |
| Abstract | Acetylcholinesterase (AChE) is a most remarkable protein, not only because it is one of the fastest enzymes in nature, but also since it appears in many molecular forms and is regulated by elaborate genetic networks. AChE is expressed in many tissues during development and in mature organisms, as well as in healthy and diseased states. In search for alternative, 'non-classical' functions of cholinesterases (ChEs), AChE could either work within the frame of classic cholinergic systems, but in non-neural tissues ('non-synaptic function'), or act non-enzymatically. Here, we review briefly some of the major ideas and advances of this field, and report on some recent progress from our own experimental work, e.g. that (i) non-neural ChEs have pronounced, predominantly enzymatic effects on early embryonic (limb) development in chick and mouse, that (ii) retinal R28 cells of the rat overexpressing synaptic AChE present a significantly decreased cell proliferation, and that (iii) in developing chick retina ACh-synthesizing and ACh-degrading cells originate from the same postmitotic precursor cells, which later form two locally opposing cell populations. We suggest that such distinct distributions of ChAT(+) vs. AChE(+) cells in the inner half retina provide graded distributions of ACh, which can direct cell differentiation and network formation. Thus, as corroborated by works from many labs, AChE can be considered a highly co-opting protein, which can combine enzymatic and non-enzymatic functions within one molecule. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Issue Number | 1 |
| Volume Number | 203 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-03-25 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Acetylcholinesterase Physiology Cell Differentiation Cell Proliferation Acetylcholine Deficiency Genetics Animals Chick Embryo Choline O-acetyltransferase Embryonic Development Humans Mice Mice, Knockout Neurons Cytology Enzymology Rats Retina Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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