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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Badole, Sachin L. Bagul, Pranita P. Mahamuni, Sagar P. Khose, Rekha D. Joshi, Anuja C. Jangam, Ganesh B. Ghule, Arvindkumar E. Raut, Chandrashekhar G. Khedkar, Vijay M. Coutinho, Evans C. |
| Description | Country affiliation: India Author Affiliation: Badole SL ( Department of Pharmacology, PES's Modern College of Pharmacy, Sector 21, Yamuna Nagar, Nigadi, Pune 411 044, India. sachinbadole8880@gmail.com) |
| Abstract | L-glutamine is a non-essential amino acid. It decreased blood sugar, stimulated insulin secretion in type 2 diabetic patients. The objective of the present investigation was to evaluate L-glutamine increases glucagon like peptide-1 (GLP-1) (7-36) amide secretion in streptozotocin-nicotinamide (STZ-NTM) induced diabetic Sprague Dawley rats. Molecular docking study was performed to elucidate the molecular basis for GLP-1 receptor agonistic activity. Type 2 diabetes was induced in overnight fasted Sprague Dawley rats pre-treated with nicotinamide (100 mg/kg, i.p.) followed by 20 min after administration of streptozotocin (55 mg/kg, i.p.). The rats were divided into; I - nondiabetic, II - diabetic control, III - sitagliptin (5 mg/kg, p.o.), IV - L-glutamine (250 mg/kg, p.o.), V - L-glutamine (500 mg/kg, p.o.) and VI - L-glutamine (1000 mg/kg, p.o.). The L-glutamine and sitagliptin treatment was 8 week. Plasma glucose was estimated every week. Body weight, food and water intake were recorded daily. Glycosylated haemoglobin, lipid profile, plasma and colonic active (GLP-1) (7-36) amide, mRNA expression of proglucagon GLP-1, plasma and pancreatic insulin, histology of pancreata and biomarkers of oxidative stress (superoxidase dismutase, reduced glutathione, malondialdehyde, glutathione peroxidase, glutathione S transferase) were measured after 8 week. In acute study, the rats were divided into I - glucose (2.5 g/kg, p.o.), II - sitagliptin (5 mg/kg, p.o.), III - L-glutamine (250 mg/kg, p.o.), IV - L-glutamine (500 mg/kg, p.o.) and V - L-glutamine (1000 mg/kg, p.o.). Plasma glucose, active GLP-1 (7-36) amide concentration and insulin levels were measured after glucose loading. The docking data indicated that l-glutamine bind to the GLP-1 receptor. L-glutamine decreased plasma glucose, increased plasma and pancreatic insulin, increased plasma and colonic active GLP-1 (7-36) amide secretion as well as decreased oxidative stress in streptozotocin-nicotinamide induced diabetic rats. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Issue Number | 2 |
| Volume Number | 203 |
| Journal | Chemico-Biological Interactions |
| e-ISSN | 18727786 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-04-25 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Blood Glucose Metabolism Diabetes Mellitus, Experimental Blood Glucagon-like Peptide 1 Secretion Glutamine Administration & Dosage Pharmacology Niacinamide Adverse Effects Peptide Fragments Administration, Oral Animals Body Weight Drug Effects Colon Physiopathology Drinking Gene Expression Regulation Genetics Glucagon-like Peptide-1 Receptor Glucose Tolerance Test Hemoglobin A, Glycosylated Insulin Lipid Metabolism Male Molecular Docking Simulation Oxidative Stress Pancreas Pathology Protein Conformation Pyrazines Rats Rats, Sprague-dawley Receptors, Glucagon Chemistry Sitagliptin Phosphate Triazoles Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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