NDLI: The single nucleotide polymorphism and haplotype analysis of MDR1 in Jiangsu Han population of China.

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The single nucleotide polymorphism and haplotype analysis of MDR1 in Jiangsu Han population of China.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Qiu, Hairong Dong, Huajie Pan, Shiyang Miao, Kourong
Spatial Coverage	China
Description	Author Affiliation: Qiu H ( Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China.)
Abstract	The aim of this study was to perform the frequency distribution of MDR1 gene SNPs and haplotypes of Jiangsu Han population in China. A total of 225 Jiangsu Han unrelated volunteers were enrolled and genotyped by PCR-ASP method at three loci: C1236T (rs1128503), G2677T/A (rs2032582) and C3435T (rs1045642). In total, C and T were found at locus 1236, with the frequency of 35% and 65%, respectively. The most frequent allele at locus 2677 was G with the frequency of 44%, followed by T (41%) and A (15%). At locus 3435, C was more common (60%) than T (40%). The most common haplotype at loci 1236-2677-3435 was T-T-T (31.84%), at loci 1236-2677 was T-T (37.68%), at loci 2677-3435 was G-C (39.06%), and at loci 1236-3435 was T-T (34.28%). The haplotype linkage disequilibrium study found that all three loci were in linkage disequilibrium, such as T-T at loci 1236-2677, T-T at loci 2677-3435 and C-C at loci 1236-3435 (P<0.01). The dendrogram study indicated that the distribution of MDR1 SNPs in Jiangsu Han population were close to Japan and Malay populations and far away from European countries. These findings could shade new lights in population genetics and anthropology studies of Han-Chinese. It also provides basic data for research on MDR1 gene polymorphism, disease association and drug resistance study.
File Format	HTM / HTML
ISSN	07533322
Issue Number	6
Volume Number	66
e-ISSN	19506007
Journal	Biomedicine & Pharmacotherapy
Language	English
Publisher	Elsevier
Publisher Date	2012-09-01
Publisher Place	France
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Asian Continental Ancestry Group Genetics P-glycoprotein Polymorphism, Single Nucleotide Alleles China Exons Gene Frequency Genetic Loci Genetics, Population Methods Haplotypes Humans Linkage Disequilibrium Metabolism P-glycoproteins Phylogeny Polymerase Chain Reaction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology

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