NDLI: Tissue distribution study of columbianadin and its active metabolite columbianetin in rats.

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Tissue distribution study of columbianadin and its active metabolite columbianetin in rats.

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Tissue distribution study of columbianadin and its active metabolite columbianetin in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, You-Bo Yang, Xiu-Wei
Description	Author Affiliation: Zhang YB ( State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing, 100191, People's Republic of China.); Yang XW ( State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing, 100191, People's Republic of China.)
Abstract	Columbianadin, one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious pharmacological effects in previous studies. In this study, a valid and sensitive reverse-phase high-performance liquid chromatography (RP-HPLC) method was established and validated for the determination of columbianadin (CBN) and its active metabolite columbianetin (CBT) in rat tissue samples. Sample separation was performed on an RP-HPLC column using a mobile phase of MeOH-H2 O (75:25, v/v) at a flow rate of 1.0 mL/min. The UV absorbance of the samples was measured at the wavelength 325 nm. The calibration curves for CBN were linear over the ranges of 0.5-20 µg/g for brain, testes and muscle, 1.0-10.0 µg/g for stomach and intestine, and 0.2-20.0 µg/g for heart, liver, spleen, lung and kidney. The calibration curves for CBT were linear over the ranges of 0.5-25 µg/g for stomach and intestine, and 0.1-10.0 µg/g for heart, liver, spleen, lung and kidney. The analysis method was successfully applied to a tissue distribution study of CBN and CBT after intravenous administration of CBN to rats. The results of this study indicated that CBN could be detected in all of the selected tissues after i.v. administration. CBN was distributed to rat tissues rapidly and could be metabolized to CBT in most detected tissues. Of the detected tissues, heart had the highest uptake of CBN, which suggested that heart might be one of the main target tissues of CBN. Concentrations of CBT were obviously higher in the digestive system than in other assayed tissues. The information provided by this research is very useful for gaining knowledge of the capacities of CBN and CBT to access different tissues.
File Format	HTM / HTML
ISSN	02693879
Issue Number	2
Volume Number	30
e-ISSN	10990801
Journal	Biomedical Chromatography
Language	English
Publisher	Wiley
Publisher Date	2016-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Analytical Chemistry Discipline Molecular Biology Discipline Biochemistry Discipline Pharmacology Coumarins Analysis Pharmacokinetics Animals Chromatography, High Pressure Liquid Chromatography, Reverse-phase Chemistry Linear Models Male Rats Rats, Sprague-dawley Reproducibility Of Results Sensitivity And Specificity Tissue Distribution Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Analytical Chemistry Drug Discovery Clinical Biochemistry Biochemistry Molecular Biology Pharmacology

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