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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rangkaew, Noppadon Suttisri, Rutt Moriyasu, Masataka Kawanishi, Kazuko |
| Description | Country affiliation: Thailand Author Affiliation: Rangkaew N ( Department of Pharmaceutical Botany, Chulalongkorn University, Bangkok, 10330, Thailand.) |
| Abstract | Investigation of the chemical constituents of the fruits of Knema glauca (Myristicaceae) yielded a new acyclic diterpene acid, named glaucaic acid 4, together with four acylphenols, including 1-(2,6-dihydroxyphenyl) tetradecan-1-one 1, malabaricone A 6, dodecanoylphloroglucinol 7 and 1-(2,4,6-trihydroxyphenyl)-9-phenylnonan-1-one 8, two lignans sesamin 2 and asarinin 3, and a flavan, myristinin D 5. In addition, myristinin A 9 and (+/-)-7,4'-dihydroxy-3'-methoxyflavan 10 were isolated from its leaves and stems, respectively. When tested against small-cell lung cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines, compounds 1, 6-8 and 10 displayed weak to moderate cytotoxicity. The acylphenols 6-8 displayed antituberculosis activity against the microbe Mycobacterium tuberculosis with MIC values of 25, 50 and 100 microg/mL, respectively, and antiviral activity against herpes simplex virus type 1, with 7 as the most active compound (IC(50) = 3.05 microg/mL). Malabaricone A 6 was also active against the malarial parasite Plasmodium falciparum with an IC(50) value of 2.78 microg/mL. |
| File Format | HTM / HTML |
| ISSN | 02536269 |
| Issue Number | 5 |
| Volume Number | 32 |
| e-ISSN | 19763786 |
| Journal | Archives of Pharmacal Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2009-05-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Antimalarials Isolation & Purification Antineoplastic Agents, Phytogenic Antitubercular Agents Antiviral Agents Diterpenes Hydrocarbons, Acyclic Myristicaceae Chemistry Animals Pharmacology Cell Line, Tumor Cell Survival Drug Effects Dose-response Relationship, Drug Fruit Humans Inhibitory Concentration 50 Microbial Sensitivity Tests Molecular Structure Mycobacterium Tuberculosis Growth & Development Plant Leaves Plant Stems Plasmodium Falciparum Simplexvirus Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine |
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