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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Seok, Sun Mi Kim, Jae Mi Park, Tae Yeop Baik, Eun Joo Lee, Soo Hwan |
| Description | Author Affiliation: Seok SM ( Department of Physiology, Ajou University School of Medicine, #5, Wonchon-dong, Suwon, 443-749, Republic of Korea.) |
| Abstract | Fructose-1,6-bisphosphate (FBP), a glycolytic intermediate, has neuroprotective effects in various brain injury models. However, its effects on blood-brain barrier (BBB) are largely unknown. In this study, we investigated the effects of FBP on lipopolysaccharide (LPS)-induced BBB dysfunction in in vitro BBB model comprising co-culture of mouse brain endothelial cell line, bEnd.3 and mouse primary astrocyte and explored its action mechanism therein involved. LPS induced the impairment of endothelial permeability and transendothelial electrical resistance (TEER). The functional changes were confirmed by alterations in immunostaining for junctional proteins occludin, ZO-1 and VE-cadherin, such as the loss of cortical staining pattern and appearance of intercellular gaps in endothelial cells. Co-administration of FBP alleviated the deleterious effects of LPS on BBB permeability and TEER in a dose dependent manner. And also FBP inhibited the LPS-induced changes in the distribution of endothelial junctional proteins, resulting in the better preservation of monolayer integrity. FBP suppressed the production of reactive oxygen species (ROS) but did not affect cyclooxygenase-2 expression and prostaglandin E2 production in endothelial cells stimulated with LPS. Taken together, these data suggest that FBP could ameliorate LPS-induced BBB dysfunction through the maintenance of junctional integrity, which might be mediated by downregulation of ROS production. |
| File Format | HTM / HTML |
| ISSN | 02536269 |
| Issue Number | 9 |
| Volume Number | 36 |
| e-ISSN | 19763786 |
| Journal | Archives of Pharmacal Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2013-09-01 |
| Publisher Place | Korea (South) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Astrocytes Drug Effects Blood-brain Barrier Cerebral Cortex Endothelium, Vascular Fructosediphosphates Pharmacology Neuroprotective Agents Animals Animals, Newborn Cytology Metabolism Cell Line Cell Membrane Permeability Cells, Cultured Blood Supply Coculture Techniques Human Umbilical Vein Endothelial Cells Humans Lipopolysaccharides Antagonists & Inhibitors Toxicity Mice Mice, Inbred Icr Rats Reactive Oxygen Species Tight Junction Proteins Tight Junctions Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine |
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