NDLI: Atrazine reduces reproduction in fathead minnow (Pimephales promelas).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tillitt, Donald E. Papoulias, Diana M. Whyte, Jeffrey J. Richter, Catherine A.
Description	Country affiliation: United States Author Affiliation: Tillitt DE ( Columbia Environmental Research Center, U.S. Geological Survey, 4200 New Haven Road, Columbia, MO 65201, USA. dtillitt@usgs.gov)
Abstract	Atrazine, the widely used herbicide, has shown to affect the hypothalamus-pituitary-gonad axis in certain vertebrate species, but few studies have examined reproductive effects of this chemical on fish. Our study was designed to evaluate a population endpoint (egg production) in conjunction with histological (e.g., gonad development) and biochemical (e.g., hormone production) phenotypes associated with atrazine exposure in fathead minnows. Adult virgin breeding groups of 1 male and 2 females were exposed to nominal concentrations of 0, 0.5, 5.0, and 50 microg/L of atrazine in a flow-through diluter for 14 or 30 days. Total egg production was lower (19-39%) in all atrazine-exposed groups as compared to the controls. The decreases in cumulative egg production of atrazine treated fish were significant by 17-20 days of exposure. Reductions in egg production in atrazine treatment groups were most attributable to reduced numbers of spawning events with increased atrazine exposure concentrations. Gonad abnormalities were observed in both male and female fish of atrazine-exposed fish. Our results also indicate that atrazine reduces egg production through alteration of final maturation of oocytes. The reproductive effects observed in this study warrant further investigation and evaluation of the potential risks posed by atrazine, particularly feral populations of fish from streams in agricultural areas with high use of this herbicide.
File Format	HTM / HTML
ISSN	0166445X
Issue Number	2
Volume Number	99
e-ISSN	18791514
Journal	Aquatic Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2010-08-15
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology Atrazine Toxicity Cyprinidae Physiology Herbicides Reproduction Drug Effects Water Pollutants, Chemical Animals Female Gonads Male Oviposition Journal Article Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Aquatic Science

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