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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Brinke, Marvin Höss, Sebastian Fink, Guido Ternes, Thomas A. Heininger, Peter Traunspurger, Walter |
| Description | Country affiliation: Germany Author Affiliation: Brinke M ( University of Bielefeld, Department of Animal Ecology, Morgenbreede 45, 33615 Bielefeld, Germany. marvin.brinke@uni-bielefeld.de) |
| Abstract | Ivermectin is a widely applied veterinary pharmaceutical that is highly toxic to several non-target organisms. So far, little is known about its impact on benthic freshwater species, although its rapid sorption to sediment particles and high persistence in aquatic sediments have raised concerns about the risk for benthic organisms. In the present study, indoor microcosms were used to assess the impact of ivermectin on freshwater meiobenthic communities over a period of 224 days. Microcosm sediments were directly spiked with ivermectin to achieve nominal concentrations of 0.9, 9, and 45 microg kg(-1) dw. Initially measured ivermectin concentrations (day 0) were 0.6, 6.2, and 31 microg kg(-1) dw. In addition to abundance of major meiobenthic organism groups, the nematode community was assessed on the species level, assuming a high risk for free-living nematodes due to their close phylogenetic relationship to the main target organisms of ivermectin, parasitic nematodes. Benthic microcrustaceans (cladocerans, ostracods) and nematodes showed the most sensitive response to ivermectin, while tardigrades profited from the presence of the pharmaceutical. The most pronounced effects on the meiofauna community composition occurred at the highest treatment level (31 microg kg(-1) dw), leading to a no observed effect concentration (NOEC(Community)) of 6.2 microg kg(-1) dw. However, the nematode community was already seriously affected at a concentration of 6.2 microg kg(-1) dw with two bacterivorous genera, Monhystera and Eumonhystera, being the most sensitive, whereas species of omnivorous genera (Tripyla, Tobrilus) increased in abundance after the application of ivermectin. Thus, a NOEC(Community) of 0.6 microg kg(-1) dw was derived for nematodes. Direct and indirect effects of ivermectin on meiobenthic communities could be demonstrated. The pharmaceutical is likely to pose a high risk, because its NOECs are close to predicted environmental concentrations (PECs) in sediments (0.45-2.17 microg kg(-1) dw), resulting in worst case risk quotients (RQs) of 1.05-36.2. This observation lends support to efforts aimed at preventing the repeated entry of ivermectin in aquatic environments and thus its accumulation in sediments. Moreover, this study points out that model ecosystem studies should be part of environmental risk assessments (ERAs) of veterinary medicinal products (VMPs). |
| File Format | HTM / HTML |
| ISSN | 0166445X |
| Issue Number | 2 |
| Volume Number | 99 |
| e-ISSN | 18791514 |
| Journal | Aquatic Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-08-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Antiparasitic Agents Toxicity Ecosystem Fresh Water Invertebrates Drug Effects Ivermectin Water Pollutants, Chemical Animals Crustacea Chemistry Nematoda Oligochaeta Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Aquatic Science |
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