NDLI: Lean body mass and muscle function in head and neck cancer patients and healthy individuals--results from the DAHANCA 25 study.

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Lean body mass and muscle function in head and neck cancer patients and healthy individuals--results from the DAHANCA 25 study.

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Lean body mass and muscle function in head and neck cancer patients and healthy individuals--results from the DAHANCA 25 study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lønbro, Simon Dalgas, Ulrik Primdahl, Hanne Johansen, Jørgen Nielsen, Jakob Lindberg Overgaard, Jens Overgaard, Kristian
Description	Country affiliation: Denmark Author Affiliation: Lønbro S ( Department of Experimental Clinical Oncology, Aarhus University Hospital , Aarhus , Denmark.)
Abstract	INTRODUCTION: Loss of lean body mass is common following radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) and may reduce maximal muscle strength and functional performance. However, the associations between lean body mass, muscle strength and functional performance are unclear and no studies in HNSCC patients have compared the levels of these variables to the levels seen in healthy individuals. PURPOSE: The purpose of the present study was to investigate the associations between lean body mass, maximal muscle strength and functional performance in HNSCC patients and to compare the levels of these variables after radiotherapy and after progressive resistance training with the levels in healthy individuals. MATERIAL AND METHODS: Lean body mass (dual energy X-ray absorptiometry), maximal muscle strength (isokinetic dynamometry) and functional performance (10 m max gait speed, 30 s chair rise, 30 s arm curl, stair climb) from HNSCC patients from the DAHANCA 25 trials and data from 24 healthy individuals were included. RESULTS: Lean body mass and maximal muscle strength were significantly associated according to the gender and age-adjusted linear regression model (p < 0.0001). In addition, maximal muscle strength were associated with 30 s arm curl performance, 10 m max gait speed and 30 s chair rise (p < 0.0001). Multiple regression analyses showed that HNSCC patients expressed significant lower levels of the investigated variables after radiotherapy than healthy individuals (p < 0.0001), and that all differences were evened out after training. CONCLUSIONS: Significant associations were found between lean body mass, maximal muscle strength and functional performance in HNSCC patients. Patients expressed lower levels of these variables compared with healthy individuals, suggesting that lean body mass is a clinically relevant health factor in HNSCC patients.
File Format	HTM / HTML
ISSN	0284186X
e-ISSN	1651226X
Journal	Acta Oncologica
Issue Number	7
Volume Number	52
Language	English
Publisher	Taylor and Francis
Publisher Date	2013-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Oncology Body Composition Head And Neck Neoplasms Physiopathology Muscle Strength Physiology Psychomotor Performance Resistance Training Thinness Case-control Studies Radiotherapy Prognosis Radiotherapy Dosage Clinical Trial Comparative Study Multicenter Study Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Hematology Oncology

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