NDLI: CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation.

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CXCR2 agonists in ADPKD liver cyst fluids promote cell proliferation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Amura, Claudia R. Brodsky, Kelley S. Gitomer, Berenice McFann, Kim Lazennec, Gwendal Nichols, Matthew T. Jani, Alkesh Schrier, Robert W. Doctor, R. Brian
Description	Country affiliation: United States Author Affiliation: Amura CR ( Division of Gastroenterology, Department of Medicine, University of Colorado Health Sciences Center, Box B-146, Denver, CO 80262, USA.)
Abstract	Autosomal dominant polycystic kidney disease (ADPKD) is a highly prevalent genetic disease that results in cyst formation in kidney and liver. Cytokines and growth factors secreted by the cyst-lining epithelia are positioned to initiate autocrine/paracrine signaling and promote cyst growth. Comparative analyses of human kidney and liver cyst fluids revealed disparate cytokine/growth factor profiles. CXCR2 agonists, including IL-8, epithelial neutrophil-activating peptide (ENA-78), growth-related oncogene-alpha (GRO-alpha), are potent proliferative agents that were found at high levels in liver but not kidney cyst fluids. Liver cysts are lined by epithelial cells derived from the intrahepatic bile duct (i.e., cholangiocytes). In polarized pkd2(WS25/-) mouse liver cyst epithelial monolayers, CXCR2 agonists were released both apically and basally, indicating that they may act both on the endothelial and epithelial cells within or lining the cyst wall. IL-8 and human liver cyst fluid induced cell proliferation of HMEC-1 cells, a human microvascular endothelial cell line, and Mz-ChA1 cells, a human cholangiocyte cell model. IL-8 expression can be regulated by specific stresses. Hypoxia and mechanical stretch, two likely stressors acting on the liver cyst epithelia, significantly increased IL-8 secretion and promoter activity. AP-1, c/EBP, and NF-kappaB were required but not sufficient to drive the stress-induced increase in IL-8 transcription. An upstream element between -272 and -1,481 bp allowed for the stress-induced increase in IL-8 transcription. These studies support the hypothesis that CXCR2 signaling promotes ADPKD liver cyst growth.
File Format	HTM / HTML
ISSN	03636143
e-ISSN	15221563
DOI	10.1152/ajpcell.00457.2007
Journal	American Journal of Physiology - Cell Physiology
Issue Number	3
Volume Number	294
Language	English
Publisher	American Physiological Society
Publisher Date	2008-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cell Biology Cell Proliferation Cyst Fluid Metabolism Cysts Interleukin-8 Liver Diseases Liver Polycystic Kidney, Autosomal Dominant Complications Receptors, Interleukin-8b Animals Cell Hypoxia Cell Line Cell Line, Tumor Cell Polarity Drug Effects Cell Shape Cells, Cultured Chemokine Cxcl1 Chemokine Cxcl5 Pathology Endothelial Cells Epithelial Cells Genetics Pharmacology Kidney Etiology Mice Mice, Inbred C57bl Mice, Knockout Polymorphism, Single Nucleotide Promoter Regions, Genetic Agonists Signal Transduction Stress, Mechanical Trpp Cation Channels Transcription, Genetic Transfection Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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