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Fast calcium wave propagation mediated by electrically conducted excitation and boosted by CICR.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kusters, J. M. A. M. Van Meerwijk, W. P. M. Ypey, D. L. Theuvenet, A. P. R. Gielen, C. C. A. M.
Description	Country affiliation: Netherlands Author Affiliation: Kusters JM ( Department of Biophysics, Radboud University Nijmegen, Nijmegen, The Netherlands.)
Abstract	We have investigated synchronization and propagation of calcium oscillations, mediated by gap junctional excitation transmission. For that purpose we used an experimentally based model of normal rat kidney (NRK) cells, electrically coupled in a one-dimensional configuration (linear strand). Fibroblasts such as NRK cells can form an excitable syncytium and generate spontaneous inositol 1,4,5-trisphosphate (IP(3))-mediated intracellular calcium waves, which may spread over a monolayer culture in a coordinated fashion. An intracellular calcium oscillation in a pacemaker cell causes a membrane depolarization from within that cell via calcium-activated chloride channels, leading to an L-type calcium channel-based action potential (AP) in that cell. This AP is then transmitted to the electrically connected neighbor cell, and the calcium inflow during that transmitted AP triggers a calcium wave in that neighbor cell by opening of IP(3) receptor channels, causing calcium-induced calcium release (CICR). In this way the calcium wave of the pacemaker cell is rapidly propagated by the electrically transmitted AP. Propagation of APs in a strand of cells depends on the number of terminal pacemaker cells, the L-type calcium conductance of the cells, and the electrical coupling between the cells. Our results show that the coupling between IP(3)-mediated calcium oscillations and AP firing provides a robust mechanism for fast propagation of activity across a network of cells, which is representative for many other cell types such as gastrointestinal cells, urethral cells, and pacemaker cells in the heart.
File Format	HTM / HTML
ISSN	03636143
e-ISSN	15221563
Journal	American Journal of Physiology - Cell Physiology
Issue Number	4
Volume Number	294
Language	English
Publisher	American Physiological Society
Publisher Date	2008-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Cell Biology Calcium Signaling Physiology Calcium Metabolism Action Potentials Animals Calcium Channels, L-type Cells, Cultured Electric Conductivity Fibroblasts Gap Junctions Inositol 1,4,5-trisphosphate Inositol 1,4,5-trisphosphate Receptors Kidney Cytology Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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