NDLI: Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chai, Orit Sommer, Adi Zimmerman, Gabriel Soreq, Hermona Friedman, Alon Bdolah-Abram, Tali Aroch, Itamar Shamir, Merav H.
Spatial Coverage	Israel
Description	Author Affiliation: Chai O ( Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot 76100, Israel. Electronic address: oritchai@yahoo.com.)
Abstract	Recent studies in animal models have focused on the role of cholinergic elements, mainly acetylcholinesterase (AChE) and the 'readthrough' acetylcholinesterase isoform (AChE-R), in seizures. A prospective double-masked study was conducted to assess the activity of AChE and AChE-R in cerebrospinal fluid (CSF) of 26 dogs post-seizure, 28 dogs with intervertebral disc disease (IVDD) and 16 healthy dogs. AChE was also measured in the serum in the post-seizure and IVDD groups. The results showed no significant differences in CSF AChE among the three groups. AChE-R was not detected in any dog and AChE in the serum was similar between groups. This preliminary study provides new information on AChE and AChE-R in the CSF and sera of dogs following naturally-occurring seizures.
File Format	HTM / HTML
ISSN	10900233
Issue Number	1
Volume Number	198
e-ISSN	15322971
Journal	The Veterinary Journal
Language	English
Publisher	Elsevier
Publisher Date	2013-10-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Prospective Studies Cerebrospinal Fluid Discipline Veterinary Medicine Dithionitrobenzoic Acid Double-blind Method Male Colorimetry Acetylcholinesterase Metabolism Blood Journal Article Physiopathology Animals Dog Diseases Dogs Statistics, Nonparametric Electrophoresis Female Israel Enzymology Veterinary Seizures
Content Type	Text
Resource Type	Article
Subject	Veterinary Animal Science and Zoology

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