NDLI: Specific biomarkers of receptors, pathways of inhibition and targeted therapies: clinical applications.

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Methodology of diffusion-weighted, diffusion tensor and magnetisation transfer imaging.

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Imaging hypoxia in gliomas

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Specific biomarkers of receptors, pathways of inhibition and targeted therapies: pre-clinical developments.

Specific biomarkers of receptors, pathways of inhibition and targeted therapies: clinical applications.

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Clinical applications of imaging biomarkers. Part 3. The neuro-oncologist's perspective.

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Diagnosis and treatment in neuro-oncology: an oncological perspective.

Biology, genetics and imaging of glial cell tumours.

The changing face of brain tumours. Preface.

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Specific biomarkers of receptors, pathways of inhibition and targeted therapies: clinical applications.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Waerzeggers, Y. Ullrich, R. T. Monfared, P. Viel, T. Weckesser, M. Stummer, W. Schober, O. Winkeler, A. Jacobs, A. H.
Description	Country affiliation: Germany Author Affiliation: Waerzeggers Y ( European Institute for Molecular Imaging, Westfaelische Wilhelms-University, Muenster, Germany.)
Abstract	A deeper understanding of the role of specific genes, proteins, pathways and networks in health and disease, coupled with the development of technologies to assay these molecules and pathways in patients, promises to revolutionise the practice of clinical medicine. In particular, the discovery and development of novel drugs targeted to disease-specific alterations could benefit significantly from non-invasive imaging techniques assessing the dynamics of specific disease-related parameters. Here we review the application of imaging biomarkers in the management of patients with brain tumours, especially malignant glioma. This first part of the review focuses on imaging biomarkers of general biochemical and physiological processes related to tumour growth such as energy, protein, DNA and membrane metabolism, vascular function, hypoxia and cell death. These imaging biomarkers are an integral part of current clinical practice in the management of primary brain tumours. The second article of the review discusses the use of imaging biomarkers of specific disease-related molecular genetic alterations such as apoptosis, angiogenesis, cell membrane receptors and signalling pathways. Current applications of these biomarkers are mostly confined to experimental small animal research to develop and validate these novel imaging strategies with future extrapolation in the clinical setting as the primary objective.
File Format	HTM / HTML
ISSN	00071277
DOI	10.1259/bjr/76389842
Journal	The British Journal of Radiology
Volume Number	84 Spec No 2
Language	English
Publisher	BIR Publications
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Therapy Research Support, Non-u.s. Gov't Tumor Markers, Biological Signal Transduction Magnetic Resonance Spectroscopy Neovascularization, Pathologic Tomography, Emission-computed, Single-photon Metabolism Brain Neoplasms Diagnostic Imaging Magnetic Resonance Imaging Glioma Diagnosis Positron-emission Tomography Discipline Radiology Apoptosis
Content Type	Text
Resource Type	Article

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