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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nasehi, Mohammad Nasehi, Maryam Rahmani-Nia, Farhad Mirzaei, Bahman Torabi-Nami, Mohammad Zarrindast, Mohammad-Reza |
| Description | Author Affiliation: Nasehi M ( Department of Biology, Faculty of Basic Sciences, Islamic Azad University Garmsar Branch, Garmsar, Iran. Electronic address: nasehi@iricss.org.); Nasehi M ( Department of Sports Science, University of Guilan, Rasht, Iran.); Rahmani-Nia F ( Department of Sports Science, University of Guilan, Rasht, Iran.); Mirzaei B ( Department of Sports Science, University of Guilan, Rasht, Iran.); Torabi-Nami M ( Institute for Cognitive Science Studies (ICSS), Tehran, Iran); Zarrindast MR ( Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran) |
| Abstract | AIMS: The aim of the present study was to investigate the effect of swimming exercise on elevated plus-maze (EPM)-associated memory deficit induced by intra-CA1 injection of scopolamine (a muscarinic acetylcholine receptor antagonist used to model Alzheimer's disease in rodents) in male mice. In addition, involvement of the mu opioid receptors in this phenomenon was investigated. MAIN METHODS: Bilateral guide cannulae were implanted to allow intra-CA1 microinjections. KEY FINDINGS: Data showed that mice with 10 and 20 days of swimming, only acquired the emotional memory, while 30 days of swimming exercise improved it. On the other hand, pretest intra-CA1 injection of scopolamine at the doses of 2 and 3 but not 1 µg/mouse reduced the emotional memory. Our results demonstrated that 20 days of swimming by itself and without any drug injection restored the emotional memory deficit induced by intra-CA1 injection of scopolamine, only at the dose of 2 but not 3 µg/mouse. Moreover, once daily injection of the subthreshold doses of morphine (2.5 and 5 mg/kg, i.p.) during the last 7 days of the 20 day-swimming intervention, improved the emotional memory deficit induced by scopolamine (3 µg/mouse) and this effect could be blocked by the subthreshold doses of naloxone (0.2 and 0.4 mg/kg). It was noted that all previous interventions did not alter the anxiety-like behaviors. SIGNIFICANCE: Swimming improved the emotional memory by itself and restored the emotional memory deficit induced by the intra-CA1 injection of scopolamine. Mu opioid receptor-dependent mechanism(s) is(are) suggested to play a role in this phenomenon. |
| File Format | HTM / HTML |
| ISSN | 00319384 |
| Volume Number | 128 |
| e-ISSN | 1873507X |
| Journal | Physiology & Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-04-10 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Exploratory Behavior Receptors, Opioid, Mu Male Morphine Pharmacology Drug Effects Chemically Induced Emotions Antagonists & Inhibitors Journal Article Physiopathology Discipline Physiology Memory Disorders Animals Naloxone Scopolamine Hydrobromide Agonists Physiology Mice Swimming Discipline Behavioral Neuroscience Physical Exertion |
| Content Type | Text |
| Resource Type | Article |
| Subject | Experimental and Cognitive Psychology Behavioral Neuroscience |
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