| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Rotella, Francis M. Badalia, Arzman Duenas, Sean M. Hossain, Maruf Saeed, Shermeen Touzani, Khalid Sclafani, Anthony Bodnar, Richard J. |
| Description |
Country affiliation: United States Author Affiliation: Rotella FM ( Behavioral and Cognitive Neuroscience Cluster of Psychology Doctoral Programs, Graduate Center, City University of New York, New York, NY, United States.); Badalia A ( Department of Psychology, Queens College, City University of New York, New York, NY, United States.); Duenas SM ( Department of Psychology, Queens College, City University of New York, New York, NY, United States.); Hossain M ( Department of Psychology, Queens College, City University of New York, New York, NY, United States.); Saeed S ( Department of Psychology, Queens College, City University of New York, New York, NY, United States.); Touzani K ( Department of Psychology, Brooklyn College, City University of New York, New York, NY, United States.); Sclafani A ( Department of Psychology, Brooklyn College, City University of New York, New York, NY, United States); Bodnar RJ ( Behavioral and Cognitive Neuroscience Cluster of Psychology Doctoral Programs, Graduate Center, City University of New York, New York, NY, United States) |
| Abstract |
A conditioned flavor preference (CFP) can be produced by pairing a flavor (conditioned stimulus, CS+) with the sweet taste of fructose. Systemic dopamine (DA) D1, D2 and NMDA, but not opioid, receptor antagonists significantly reduce the acquisition of the fructose-CFP. A conditioned flavor avoidance (CFA) can be produced by pairing a CS+flavor with the bitter taste of quinine. To evaluate whether fructose-CFP and quinine-CFA share common neurochemical substrates, the present study determined the systemic effects of DA D1 (SCH23390: SCH), DA D2 (raclopride: RAC), NMDA (MK-801) or opioid (naltrexone: NTX) receptor antagonists on the acquisition of quinine-CFA. In Experiment 1, food-restricted male rats were trained over 8 alternating one-bottle sessions to drink an 8% fructose+0.2% saccharin solution (FS) mixed with one flavor (CS-, e.g., grape) and a different flavor (CS+, e.g., cherry) mixed in a solution (FSQ) containing fructose+saccharin and quinine at 0.001-0.030% concentrations. In six subsequent two-bottle choice tests (1-3: two sessions each) with the CS- and CS+ flavors presented in FS solutions, only rats trained with 0.03% quinine displayed a CS+ avoidance in Test 1. In Experiment 2, rats received vehicle (Veh), SCH (200 nmol/kg), RAC (200 nmol/kg), MK-801 (100 µg/kg) or NTX (1 mg/kg) 30 min prior to the 8 one-bottle training sessions with CS-/FS and CS+/FSQ (0.03% quinine) solutions. An additional vehicle group (Veh 0.06%) was trained with a CS+/FSQ containing 0.06% quinine. In the two-bottle choice tests, the Veh and RAC groups avoided the CS+ flavor in Test 1 only, whereas the SCH, MK801, and NTX groups significantly avoided the CS+ in Tests 1-3. The Veh.06% group trained avoided the CS+ in Tests 1 and 2, but not Test 3. In Experiment 3, Veh and SCH groups were trained as in Experiment 2, but were tested with CS flavors presented in 0.2% saccharin solutions. The SCH group avoided the CS+ flavor in Tests 1-3 while the Veh group avoided the CS+ in Test 1 only. Thus whereas DA D1, DA D2 and NMDA, but not opioid receptor antagonism blocked acquisition of sweet taste-based CFP, DA D1, NMDA and opioid, but not DA D2 receptor antagonism enhanced the CFA produced by the bitter taste of quinine. |
| File Format |
HTM / HTML |
| ISSN |
00319384 |
| Volume Number |
128 |
| e-ISSN |
1873507X |
| Journal |
Physiology & Behavior |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2014-04-10 |
| Publisher Place |
United States |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Research Support, Non-u.s. Gov't Dizocilpine Maleate Male Conditioning (psychology) Naltrexone Antagonists & Inhibitors Journal Article Narcotic Antagonists Discipline Physiology Saccharin Benzazepines Physiology Raclopride Avoidance Learning Signal Transduction Rats Rats, Sprague-dawley Receptors, N-methyl-d-aspartate Pharmacology Quinine Fructose Receptors, Dopamine D1 Animals Receptors, Dopamine D2 Taste Dopamine D2 Receptor Antagonists Discipline Behavioral Neuroscience |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Experimental and Cognitive Psychology Behavioral Neuroscience |
