NDLI: Association between hearing loss and saccular dysfunction in older individuals.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zuniga, Maria Geraldine Dinkes, Roni E. Davalos-Bichara, Marcela Carey, John P. Schubert, Michael C. King, W. Michael Walston, Jeremy Agrawal, Yuri
Description	Country affiliation: United States Author Affiliation: Zuniga MG ( Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.)
Abstract	OBJECTIVE: 1) Describe the association between hearing loss and dysfunction of each of the 5 vestibular end-organs--the horizontal, superior, and posterior semicircular canals; saccule; and utricle--in older individuals. 2) Evaluate whether hearing loss and vestibular end-organ deficits share any risk factors. STUDY DESIGN: Cross-sectional study. SETTING: Academic medical center. PATIENTS: Fifty-one individuals age 70 years or older. INTERVENTIONS: Audiometry, head-thrust dynamic visual acuity (htDVA), sound-evoked cervical vestibular-evoked myogenic potential (cVEMP), and tap-evoked ocular VEMP (oVEMP). MAIN OUTCOME MEASURES: Audiometric pure-tone averages (PTA), htDVA LogMAR scores as a measure of semicircular canal function in each canal plane, and cVEMP and oVEMP amplitudes as a measure of saccular and utricular function, respectively. RESULTS: We observed a significant correlation between hearing loss at high frequencies and reduced cVEMP amplitudes (or reduced saccular function; r = -0.37, p < 0.0001) in subjects age 70 years or older. In contrast, hearing loss was not associated with oVEMP amplitudes (or utricular function), or htDVA LogMAR scores (or semicircular canal function) in any of the canal planes. Age and noise exposure were significantly associated with measures of both cochlear and saccular dysfunction. CONCLUSION: The concomitant decline in the cochlear and saccular function associated with aging may reflect their common embryologic origin in the pars inferior of the labyrinth. Noise exposure seems to be related to both saccular and cochlear dysfunction. These findings suggest a potential benefit of screening individuals with presbycusis-particularly those with significant noise exposure history-for saccular dysfunction, which may contribute to fall risk in the elderly.
File Format	HTM / HTML
ISSN	15317129
e-ISSN	15374505
DOI	10.1097/MAO.0b013e31826bedbc
Journal	Otology & Neurotology
Issue Number	9
Volume Number	33
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2012-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, Non-u.s. Gov't Cross-sectional Studies Saccule And Utricle Vestibular Diseases Educational Status Epidemiology Socioeconomic Factors Etiology Aging Physiology Vestibular Evoked Myogenic Potentials Hypertension Complications Risk Factors Semicircular Canals Discipline Otolaryngology Audiometry, Pure-tone Visual Acuity Physiopathology Pathology Hearing Loss, Noise-induced Bone Conduction Vestibular Function Tests Speech Perception Hearing Loss
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Sensory Systems Neurology (clinical)

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Development of conductive hearing loss due to posterior semicircular canal dehiscence.

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