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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sram, R. J. Farmer, P. Singh, R. Garte, S. Kalina, I. Popov, T. A. Binkova, B. Ragin, C. Taioli, E. |
| Description | Country affiliation: Czech Republic Author Affiliation: Sram RJ ( Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine of Academy AS CR and Health Institute of Central Bohemia, Prague, Czech Republic.) |
| Abstract | DNA adducts are markers of carcinogen exposure and of their biological effect; they have been shown to be related to mutagenesis, and therefore they could be a predictive biomarker of human cancer. The objective of this study was to assess if there is a relationship between vitamins A, C, and E, which are known to play a significant role as free radical scavengers and antioxidant agents, and biomarkers of genotoxicity and oxidative stress. Three hundred and fifty-six subjects from Czech Republic, Slovak Republic and Bulgaria, who completed a questionnaire on dietary information and had a measurement of plasma A, C, E vitamins, DNA adduct levels (benzo[a]pyrene (B[a]P) and bulky (DNA-Tot) DNA adducts) and oxidative damage (cyclic pyrimidopurinone N-1,N2 malondialdehyde-2 deoxyguanosine (M1dG) and 8-oxo-7,8-dihydro-2_deoxyguanosine (8-oxodG)) were analyzed. A significant inverse correlation was observed between plasma vitamin levels and both benzo[a]pyrene (B[a]P) and bulky DNA adducts. Vitamin A was also significantly inversely correlated with M1dG, a marker of oxidative damage. The associations were stronger in non-smokers than in smokers. Dietary intake of certain antioxidants such as vitamins is associated with reduced levels of markers of DNA damage (B[a]P and DNA-Tot) and oxidation (M1dG and 8-oxodG) measured in peripheral white blood cells. This could contribute to the protective role of such a dietary pattern on cancer risk. The protective effect of dietary vitamins is less evident in smokers. |
| File Format | HTM / HTML |
| ISSN | 13835718 |
| e-ISSN | 18793592 |
| Journal | Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
| Issue Number | 2 |
| Volume Number | 672 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-01-31 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Research Support, Non-u.s. Gov't Discipline Genetics Cross-sectional Studies Oxidative Stress Biological Markers Discipline Biochemistry Administration & Dosage Pharmacology Drug Effects Vitamins Dna Adducts Questionnaires |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Health, Toxicology and Mutagenesis |
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