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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Burdak-Rothkamm, Susanne Rothkamm, Kai Folkard, Melvyn Patel, Gaurang Hone, Pat Lloyd, David Ainsbury, Liz Prise, Kevin M. |
| Description | Country affiliation: United kingdom Author Affiliation: Burdak-Rothkamm S ( Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK.) |
| Abstract | Considerable controversy still exists as to whether electric and magnetic fields (MF) at extremely low frequencies are genotoxic to humans. The aim of this study was to test the ability of alternating magnetic fields to induce DNA and chromosomal damage in primary human fibroblasts. Single- and double-strand breaks were quantified using the alkaline comet assay and the gammaH2AX-foci assay, respectively. Chromosomal damage was assayed for unstable aberrations, sister chromatid exchange and micronuclei. Cells were exposed to switching fields - 5min on, 10min off - for 15h over the range 50-1000microT. Exposure to ionizing radiation was used as a positive-effect calibration. In this study two separate MF exposure systems were used. One was based on a custom-built solenoid coil system and the other on a commercial system almost identical to that used in previous studies by the EU REFLEX programme. With neither system could DNA damage or chromosomal damage be detected as a result of exposure of fibroblasts to switching MF. The sensitive gammaH2AX assay could also not detect significant DNA damage in the MF-exposed fibroblasts, although the minimum threshold for this assay was equivalent to an X-ray dose of 0.025Gy. Therefore, with comparable MF parameters employed, this study could not confirm previous studies reporting significant effects for both the alkaline and neutral comet assays and chromosomal aberration induction. |
| File Format | HTM / HTML |
| ISSN | 13835718 |
| e-ISSN | 18793592 |
| Journal | Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
| Issue Number | 2 |
| Volume Number | 672 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-01-31 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Cell Line Research Support, Non-u.s. Gov't Discipline Genetics Electromagnetic Fields Adverse Effects Chromosome Aberrations Discipline Biochemistry Radiation Effects Comet Assay Dna Damage |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Health, Toxicology and Mutagenesis |
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