NDLI: In vivo radioprotective potential of thymol, a monoterpene phenol derivative of cymene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Archana, P. R. Nageshwar Rao, B. Satish Rao, B. S.
Description	Country affiliation: India Author Affiliation: P R A ( Division of Radiobiology & Toxicology, Manipal University, Manipal, India.)
Abstract	The radioprotective and anticlastogenic potential of a phenol derivative monoterpene thymol(TOH), against whole-body gamma radiation was studied in Swiss albino mice. Acute toxicity of TOH, with an LD(50(14)) of 1134.03mg/kgbwt., was observed when administered intra-peritoneally (i.p.). The radioprotective potential of TOH was evaluated using the optimal dose of 10mg/kgbwt. TOH, which increased the LD(50/30) by 2.17Gy and resulted in a dose reduction factor (DRF) of 1.25. A significant (p<0.01) reduction in micronucleated, polychromatic erythrocytes (PCE), normochromatic erythrocytes (NCE), and an increased PCE/NCE ratio was also observed after administration of 10mg/kg.b.wt. TOH prior to gamma radiation, indicating its antigenotoxic effect. TOH pre-treatment significantly (p<0.01) elevated reduced glutathione, glutathione-S-transferase, catalase, and superoxide dismutase levels and decreased lipid peroxidation levels in mouse liver homogenates at 24 and 48h after exposure to 4.5Gy of radiation. Further, TOH treatment before exposure to 7.5Gy of gamma radiation resulted in a significant (p<0.01) increase in hematological parameters at various post-treatment time points, with increased numbers of endogenous spleen colonies as well. The histological observations indicated a decline in villus heights and crypt numbers in mouse jejunum and were accompanied by a significant decrease in bone marrow nucleated cells in the irradiated group, which was almost normalized by pre-treatment with TOH. Our study clearly documents the antioxidant, anticlastogenic and radioprotective potentials of TOH, which may be attributed to several possible mechanisms, such as normalization of intracellular antioxidant levels and free radical scavenging activities by TOH.
File Format	HTM / HTML
ISSN	13835718
e-ISSN	18793592
Journal	Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Issue Number	2
Volume Number	726
Language	English
Publisher	Elsevier
Publisher Date	2011-12-24
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Blood Cells Gamma Rays Intestinal Mucosa Discipline Genetics Toxicity Discipline Biochemistry Antimutagenic Agents Pharmacology Radiation-protective Agents Thymol Drug Effects Antioxidants Animals Bone Marrow Cells Micronuclei, Chromosome-defective Mice Lipid Peroxidation
Content Type	Text
Resource Type	Article
Subject	Genetics Health, Toxicology and Mutagenesis

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