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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ramautar, Rawi Nevedomskaya, Ekaterina Mayboroda, Oleg A. Deelder, André M. Wilson, Ian D. Gika, Helen G. Theodoridis, Georgios A. Somsen, Govert W. de Jong, Gerhardus J. |
| Description | Country affiliation: Netherlands Author Affiliation: Ramautar R ( Department of Biomedical Analysis, Utrecht University, Sorbonnelaan 16, PO Box 80082, 3508 TB Utrecht, The Netherlands. R.Ramautar@lumc.nl) |
| Abstract | The potential of capillary electrophoresis time-of-flight mass spectrometry (CE-TOF-MS) using capillaries coated with a triple layer of polybrene-dextran sulfate-polybrene (PB-DS-PB) was evaluated for metabolic profiling of human urine. The method covers various metabolite classes and stable metabolic profiles of urine samples were obtained with favourable migration time repeatability (RSDs <1%). The PB-DS-PB CE-TOF-MS method was used for the analysis of human urine samples from 30 males and 30 females, which had been previously analyzed by reversed-phase UPLC-TOF-MS. Multivariate data analysis of the obtained data provided clear distinction between urine samples from males and females, emphasizing gender differences in metabolic signatures. Nearly all compounds responsible for male-female classification in CE-TOF-MS were different from the classifying compounds in UPLC-TOF-MS. Almost all compounds causing classification in the CE-TOF-MS study were highly polar and did not exhibit retention in the reversed-phase UPLC system. In addition, the CE-TOF-MS classifiers had an m/z value in the range of 50-150, whereas 95% of the classifying features found with UPLC-TOF-MS had an m/z value above 150. The CE-TOF-MS method therefore appears to be highly complementary to the UPLC-TOF-MS method providing classification based on different classes of metabolites. |
| File Format | HTM / HTML |
| ISSN | 1742206X |
| Issue Number | 1 |
| Volume Number | 7 |
| e-ISSN | 17422051 |
| Journal | Molecular BioSystems |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Publisher Date | 2011-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Molecular Biology Discipline Biochemistry Chromatography, Liquid Electrophoresis, Capillary Mass Spectrometry Metabolome Urine Chemistry Female Humans Male Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Biotechnology |
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