NDLI: Which CIDE are you on? Apoptosis and energy metabolism.

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Which CIDE are you on? Apoptosis and energy metabolism.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yonezawa, Tomo Kurata, Riho Kimura, Minoru Inoko, Hidetoshi
Description	Country affiliation: Japan Author Affiliation: Yonezawa T ( Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Bohseidai, Ishehara, Kanagawa 259-1193, Japan. yonet2301@yahoo.co.jp)
Abstract	Around 1998, cell death-inducing DNA fragmentation factor-alpha (DFFA)-like effector (CIDE) proteins including CIDEA, CIDEB and CIDEC/fat specific protein 27 (Fsp27) were first identified by their sequence homology with the N-terminal domain of the DNA fragmentation factor (DFF). Indeed, in vitro analysis revealed that all three CIDE proteins are involved in apoptosis. However, recent gene-targeting studies have provided novel insights into the physiological function of CIDE proteins. Mice deficient in each CIDE protein exhibit lean phenotypes, a reduction of lipid droplet size in white adipose tissue and increased metabolic rate. Thus, all CIDE proteins play an important role in energy metabolism and lipid droplet formation. More recently, a glycoproteomics approach has shown that post-translational regulation of CIDE proteins via glycosylation modulates transforming growth factor (TGF)-beta 1-dependent apoptosis. Another recent study using mouse embryonic fibroblasts derived from CIDEA-deficient mice revealed that 5'AMP-activated protein kinase (AMPK) activity is regulated by CIDEA-mediated ubiquitin-dependent proteasomal degradation via a protein interaction with the AMPK beta subunit. Even after a decade of study, the physiological roles of CIDE proteins have still not been completely elucidated. This review aims to shed light on the novel functions of CIDE proteins and their physiological roles.
File Format	HTM / HTML
ISSN	1742206X
Issue Number	1
Volume Number	7
e-ISSN	17422051
Journal	Molecular BioSystems
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2011-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Molecular Biology Discipline Biochemistry Apoptosis Regulatory Proteins Metabolism Apoptosis Physiology Energy Metabolism Animals Genetics Humans Mice Models, Biological Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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Integration of apoptosis and metabolism.

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Synthesis of proteins with defined posttranslational modifications using the genetic noncanonical amino acid incorporation approach.

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Inflammatory outcomes of apoptosis, necrosis and necroptosis.

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Which CIDE are you on? Apoptosis and energy metabolism.

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Which CIDE are you on? Apoptosis and energy metabolism.