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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gao, Jing Dang, Yunzhi Sun, Naiping Li, Jian Shen, Lin |
| Description | Country affiliation: China Author Affiliation: Gao J ( Key Laboratory of Carcinogenesis and Translational Research, Department of GI Oncology, Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Haidian District, Beijing, 100142, China. gaojing_pumc@yahoo.com.cn) |
| Abstract | To investigate the correlation between C-KIT/PDGFR mutations and Imatinib response or survival in Chinese advanced gastrointestinal stromal tumor (GIST) patients. Clinical data and paraffin-embedded tumor specimens were collected from 158 advanced GIST patients receiving first-line Imatinib. Mutation analyses of C-KIT gene (Exons 9, 11, 13, and 17) and PDGFR gene (exons 12 and 18) were performed by PCR amplification and Sanger sequencing. A total of 135 patients harboring C-KIT mutations (exon 11 mutation: 108; exon 9 mutation: 23; exon 13 mutation: 2; exon 17 mutation: 2) and one patients carrying PDGFR mutation (exon 18) were found in this study. Twenty-two patients (13.9 %) with neither C-KIT nor PDGFR mutations were named as wild type. The response rate (64.7 vs. 36.4 %, P = 0.000) and median progression-free survival (28 vs. 8 months, P = 0.000) of mutant patients (n = 136) were significantly higher than those of wild-type patients (n = 22). Moreover, the response rate and median progression-free survival in patients with exon 11 mutations (n = 108), exon 9 mutations (n = 23), and wild-type patients (n = 22) were 68.5, 47.8, and 36.4 % (P = 0.001), and 31 months, 13 months, and 8 months (P = 0.000), respectively. No significant differences of response rate or median progression-free survival were seen in patients with exon 11 deletion mutations, point mutations, and mixed-type mutations. C-KIT mutations were closely associated with Imatinib response and progression-free survival of Chinese advanced GIST patients. Other predictive markers for Imatinib would be further investigated. |
| File Format | HTM / HTML |
| ISSN | 13570560 |
| Issue Number | 5 |
| Volume Number | 29 |
| e-ISSN | 1559131X |
| Journal | Medical Oncology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Kaplan-meier Estimate Humans Middle Aged Drug Resistance, Neoplasm Male Journal Article Pyrimidines Genetics Adult Female Discipline Oncology Piperazines Tumor Markers, Biological Mortality Drug Therapy Proportional Hazards Models Antineoplastic Agents Reverse Transcriptase Polymerase Chain Reaction Imatinib Mesylate Therapeutic Use Disease-free Survival Asian Continental Ancestry Group Aged Benzamides Mutation Proto-oncogene Proteins C-kit Gastrointestinal Stromal Tumors Dna Mutational Analysis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
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