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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rohr, Sandra S. Pelloso, Luís Arthur Flores Borgo, Aline dos Santos de Rezende, João Garibaldi Silva, Maria Regina Regis Yamamoto, Mihoko de Lourdes L. F. Chauffaille, Maria |
| Description | Country affiliation: Brazil Author Affiliation: Rohr SS ( Disciplina de Hematologia e Hemoterapia, UNIFESP-Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740 -3.andar, São Paulo, SP, 04023-900, Brazil. sandra.rohr@gmail.com) |
| Abstract | Transformation of myelodysplastic syndrome (MDS) into acute myelogenous leukemia occurs in approximately 30 % of cases, while progression into acute lymphoblastic leukemia (ALL) is rare. We report on a 67-year-old man with the diagnosis of MDS, subtype refractory anemia with ring sideroblasts (RARS), karyotype 20q- , JAK-2 negative and grade III fibrosis on the bone marrow biopsy, who evolved into ALL 33 months after the diagnosis of MDS. RARS is one of the subtypes of MDS with most indolent course. Deletion of the long arm of chromosome 20 (20q-) is considered as good prognosis by the International Prognostic Scoring System, an important scoring system for predicting survival and evolution of MDS. Primary MDS with bone marrow fibrosis may represent a distinct clinicopathological and is supposed to have an unfavorable prognosis. The combined analysis of these features makes this rare report still more challenging and illustrates that biology of MDS is yet to be discovered. |
| File Format | HTM / HTML |
| ISSN | 13570560 |
| Issue Number | 5 |
| Volume Number | 29 |
| e-ISSN | 1559131X |
| Journal | Medical Oncology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Chromosome Deletion Primary Myelofibrosis Precursor Cell Lymphoblastic Leukemia-lymphoma Humans Anemia, Sideroblastic Immunophenotyping Male Disease Progression Journal Article Case Reports Pathology Immunology Anemia, Refractory Cell Transformation, Neoplastic Genetics Aged Chromosomes, Human, Pair 20 Discipline Oncology |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Hematology Cancer Research Oncology |
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