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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gill, Dipender Cox, Thomas Aravind, Adarsh Wilding, Peter Korompoki, Eleni Veltkamp, Roland Kar, Arindam |
| Description | Author Affiliation: Gill D ( Imperial College London, London, United Kingdom. Electronic address: dipender.gill@imperial.ac.uk.); Cox T ( Barts Health NHS Trust, London, United Kingdom.); Aravind A ( Imperial College Healthcare NHS Trust, London, United Kingdom.); Wilding P ( Imperial College Healthcare NHS Trust, London, United Kingdom.); Korompoki E ( Imperial College, College London, London, United Kingdom.); Veltkamp R ( Department of Stroke Medicine, Division of Brain Sciences, Imperial College London, London, United Kingdom.); Kar A ( Imperial College Healthcare NHS Trust, London, United Kingdom.) |
| Abstract | BACKGROUND: Outcomes are worse in patients who underwent thrombolysis for acute ischemic stroke (AIS) with persistent hypertension. The objective of this study is to investigate whether fall in systolic blood pressure (SBP) has any relationship with neurological outcome 24 hours after thrombolysis, after adjusting for potentially confounding factors. METHODS: Retrospective analysis of a single-center database of consecutive thrombolysis cases for AIS. Multivariate regression analysis was used to explore the relationship between fall in SBP and reduction in National Institutes of Health Stroke Scale (NIHSS) score 24 hours after thrombolysis. Other potentially confounding predictor variables used in the model were SBP on thrombolysis, blood glucose level on thrombolysis, NIHSS score on thrombolysis, administration of antihypertensive medications, and the time to thrombolysis after symptom onset. RESULTS: A fall in SBP 24 hours after thrombolysis is independently associated with greater improvement in NIHSS score 24 hours after thrombolysis (coefficient .051, 95% confidence interval .023-.078, P < .001). Thus, a reduction of 10 mmHg in SBP after 24 hours is associated with a .51 point reduction in the NIHSS score. CONCLUSIONS: Restoration of SBP toward normal limits after thrombolysis for AIS is associated with greater early neurological improvement. |
| File Format | HTM / HTML |
| ISSN | 10523057 |
| Issue Number | 6 |
| Journal | Journal of Stroke and Cerebrovascular Diseases |
| Volume Number | 25 |
| e-ISSN | 15328511 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-06-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Cardiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Rehabilitation Neurology (clinical) Surgery Cardiology and Cardiovascular Medicine |
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