| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Muscari, Antonio Conte, Camilla Degli Esposti, Daniela Faccioli, Luca Falcone, Roberta Kolce, Besar Marabini, Lisa Puddu, Giovanni M. Rosticci, Martina Spinardi, Luca Veronesi, Maddalena Borghi, Claudio Zoli, Marco |
| Description |
Author Affiliation: Muscari A ( Stroke Unit, Medical Department of Continuity of Care and Disability, S.Orsola-Malpighi Hospital, Bologna, Italy); Conte C ( Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.); Degli Esposti D ( Stroke Unit, Medical Department of Continuity of Care and Disability, S.Orsola-Malpighi Hospital, Bologna, Italy.); Faccioli L ( Diagnostic and Interventional Neuroradiology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy.); Falcone R ( Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.); Kolce B ( Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.); Marabini L ( Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.); Puddu GM ( Stroke Unit, Medical Department of Continuity of Care and Disability, S.Orsola-Malpighi Hospital, Bologna, Italy.); Rosticci M ( Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.); Spinardi L ( Diagnostic and Interventional Neuroradiology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy.); Veronesi M ( Stroke Unit, Medical Department of Continuity of Care and Disability, S.Orsola-Malpighi Hospital, Bologna, Italy); Borghi C ( Stroke Unit, Medical Department of Continuity of Care and Disability, S.Orsola-Malpighi Hospital, Bologna, Italy); Zoli M ( Stroke Unit, Medical Department of Continuity of Care and Disability, S.Orsola-Malpighi Hospital, Bologna, Italy) |
| Abstract |
BACKGROUND: The aim of this study was the detection of risk factors for lacunar strokes with visible lesions on computed tomography (CT) scan, considering in particular clinical characteristics, echocardiographic parameters, and carotid-femoral pulse wave velocity (PWV, a marker of large-artery stiffness). Lacunar strokes with very small or nonvisible lesions may have different risk factors. METHODS: We examined 106 patients (mean age 66.9 ± 12.3 years, 60 men), including 55 patients with clinically lacunar stroke associated with deep ischemic lesions of .3-1.5 cm on brain CT scan, and 51 control patients with cortical ischemic stroke, with lesions of 2.5-10.0 cm. RESULTS: In multiple logistic regression, with respect to cortical strokes, the following variables were independently associated with lacunar strokes: tricuspid regurgitation velocity (inverse relationship, odds ratio [OR] .13, 95% confidence interval [CI] .04-.43, P = .0007, cutoff at 228 cm/s), mean systolic blood pressure (SBP) (OR 3.98, 95% CI 2.78-7.79, P = .008, cutoff at 145 mmHg), ever-smoker status (OR 2.68, 95% CI 1.06-6.80, P = .04), and atrial fibrillation (inverse relationship, OR .11, 95% CI .01-1.00, P = .0496). In univariate analysis, the patients with lacunar stroke also had a lower prevalence of mitral regurgitation. There were no differences between the 2 groups in relation to diabetes, cholesterol, left ventricular mass and dimensions, and PWV. CONCLUSIONS: The patients with lacunar strokes with visible cerebral lesions on CT scan, compared with the patients with cortical infarct, had a lower tricuspid regurgitation velocity, a higher mean SBP, a greater prevalence of ever-smokers, and a lower prevalence of atrial fibrillation. |
| File Format |
HTM / HTML |
| ISSN |
10523057 |
| Issue Number |
6 |
| Journal |
Journal of Stroke and Cerebrovascular Diseases |
| Volume Number |
25 |
| e-ISSN |
15328511 |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2016-06-01 |
| Publisher Place |
United States |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Cardiology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Rehabilitation Neurology (clinical) Surgery Cardiology and Cardiovascular Medicine |
