| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Wang, Xin Chappell, Francesca M. Valdes Hernandez, Maria Lowe, Gordon Rumley, Ann Shuler, Kirsten Doubal, Fergus Wardlaw, Joanna M. |
| Description |
Country affiliation: United kingdom Author Affiliation: Wang X ( Division of Neuroimaging Sciences, Centre for Clinical Brain Sciences, Edinburgh, UK.); Chappell FM ( Division of Neuroimaging Sciences, Centre for Clinical Brain Sciences, Edinburgh, UK.); Valdes Hernandez M ( Division of Neuroimaging Sciences, Centre for Clinical Brain Sciences, Edinburgh, UK.); Lowe G ( Institute of Cardiovascular and Medical Sciences, Royal Infirmary, University of Glasgow, Glasgow, UK.); Rumley A ( Institute of Cardiovascular and Medical Sciences, Royal Infirmary, University of Glasgow, Glasgow, UK.); Shuler K ( Division of Neuroimaging Sciences, Centre for Clinical Brain Sciences, Edinburgh, UK.); Doubal F ( Division of Neuroimaging Sciences, Centre for Clinical Brain Sciences, Edinburgh, UK); Wardlaw JM ( Division of Neuroimaging Sciences, Centre for Clinical Brain Sciences, Edinburgh, UK. Electronic address: joanna.wardlaw@ed.ac.uk.) |
| Abstract |
BACKGROUND AND OBJECTIVE: Recent studies suggest perivascular spaces are a marker of small vessel disease, blood-brain barrier permeability, and inflammation, but little is known about their risk factors and associations with peripheral blood markers. MATERIALS AND METHODS: In prospectively recruited patients with recent minor ischemic stroke, we investigated the influence of age, sex, hypertension, diabetes, and smoking on the severity of perivascular spaces in the basal ganglia seen on T2-weighted magnetic resonance imaging. We assessed plasma markers of endothelial function (von Willebrand factor, intracellular adhesion molecule-1), inflammation (interleukin-6, tumor necrosis factor-alpha, C-reactive protein), and thrombosis (fibrinogen, prothrombin fragments 1 + 2, thrombin-antithrombin complex, tissue plasminogen activator, D-dimer). We used a validated semi-automated method to measure basal ganglia perivascular spaces count and volume. We tested uni- and multivariable associations between blood markers and basal ganglia perivascular spaces count and volume. FINDINGS: In 100 patients (median age: 67 years, range: 37-92), on adjusted analysis, basal ganglia perivascular spaces count was associated with age (r = .117, P = .003) and hypertension (r = 2.225, P = .013). On multivariable linear regression, adjusted for age, sex, hypertension, smoking and diabetes, reduced von Willebrand factor was associated with increased basal ganglia perivascular spaces count (r = -.025, P = .032). CONCLUSION: The association of increased basal ganglia perivascular spaces count with reduced von Willebrand factor is novel. As von Willebrand factor may promote cerebral endothelial integrity, insufficient von Willebrand factor is consistent with dysfunctional cerebral endothelium and increased basal ganglia perivascular spaces in cerebral small vessel disease. Quantitative perivascular spaces measurement may increase sensitivity to detect cerebral endothelial dysfunction. |
| File Format |
HTM / HTML |
| ISSN |
10523057 |
| Issue Number |
12 |
| Journal |
Journal of Stroke and Cerebrovascular Diseases |
| Volume Number |
25 |
| e-ISSN |
15328511 |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2016-12-01 |
| Publisher Place |
United States |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Cardiology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Rehabilitation Neurology (clinical) Surgery Cardiology and Cardiovascular Medicine |
