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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Satoh, Hiroshi Amagase, Kikuko Takeuchi, Koji |
| Description | Country affiliation: Japan Author Affiliation: Satoh H ( Department of Pharmacology & Experimental Therapeutics, Division of Pathological Science, Kyoto Pharmaceutical University, Kyoto, Japan.) |
| Abstract | Antisecretory drugs such as histamine H2-receptor antagonists and proton pump inhibitors are commonly used for the treatment of upper gastrointestinal mucosal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs). However, it has recently been reported that these drugs exacerbate NSAID-induced small intestinal lesions in rats. Unfortunately, there are few effective agents for the treatment of this complication. We examined the effects of mucosal protective agents (MPAs) (misoprostol, irsogladine, and rebamipide) and mucin of porcine stomach on diclofenac-induced intestinal lesions and the exacerbation of the lesions by ranitidine or omeprazole. The effects of the drugs on intestinal motility and mucus distribution/content were also examined. Male Wistar rats (180-220 g) were used. Each drug was administered orally under fed conditions. Diclofenac (1-10 mg/kg) produced multiple lesions in the small intestine dose-dependently. Both ranitidine (30 mg/kg) and omeprazole (100 mg/kg) significantly increased the intestinal lesions induced by low doses (3 and 6 mg/kg) of diclofenac. Misoprostol (0.03-0.3 mg/kg), irsogladine (3-30 mg/kg), and rebamipide (30-300 mg/kg), as well as mucin (30-300 mg/kg) inhibited the formation of intestinal lesions caused by a high dose (10 mg/kg) of diclofenac alone and prevented the exacerbation of diclofenac-induced lesions by antisecretory drugs. Diclofenac (10 mg/kg) markedly increased the intestinal motility and decreased the mucosal mucus, and the decrease of mucus was significantly inhibited by the MPAs. These results indicate the usefulness of the MPAs for the treatment of intestinal lesions induced by NSAIDs alone or by coadministration with antisecretory drugs, and suggest that mucus plays an important role in the protection of intestinal mucosa by the MPAs. |
| File Format | HTM / HTML |
| ISSN | 00223565 |
| Issue Number | 2 |
| Volume Number | 348 |
| e-ISSN | 15210103 |
| Journal | Journal of Pharmacology and Experimental Therapeutics |
| Language | English |
| Publisher | American Society for Pharmacology and Experimental Therapeutics |
| Publisher Date | 2014-02-01 |
| Publisher Place | United States |
| Access Restriction | Subscribed |
| Subject Keyword | Triazines Comparative Study Rats, Wistar Male Mucus Discipline Pharmacology Misoprostol Journal Article Diclofenac Quinolones Dose-response Relationship, Drug Anti-inflammatory Agents, Non-steroidal Gastric Mucins Gastrointestinal Agents Anti-ulcer Agents Intestinal Mucosa Alanine Adverse Effects Intestine, Small Proton Pump Inhibitors Prevention & Control Protective Agents Secretion Intestinal Diseases Rats Administration & Dosage Drug Effects Therapeutic Use Chemically Induced Omeprazole Pathology Animals Discipline Therapeutics Ranitidine Sus Scrofa Analogs & Derivatives |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Medicine Pharmacology |
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