NDLI: Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats.

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Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats.

Content Provider	Semantic Scholar
Author	Kim, Jeong Wook Jeon, Woo Kyu Yun, Jung Won Park, Dong Il Cho, Yong Kyun Sohn, Chung Il Kim, Byung Ik Yeom, Joon Sup Park, Hyo Soon Kim, Eun Jeong Shin, Myong Suk
Copyright Year	2005
Abstract	The aim of this study was to examine whether bovine colostrum was able to prevent the NSAID induced small intestinal damage in animals. The animal model population of the study consisted of 4 groups: control group, diclofenac group, diclofenac with 10% low fat milk group and diclofenac with 5% colostrum group. The animals with milk or colostrum were fed with 10% low fat milk or 5% colostral solution for 5 days before the administration of diclofenac. Gut injuries were induced by administration of a single dose of diclofenac (100 mg/kg orally). Epithelial permeability values (24 hour urinary excretion of 51Cr-ethylenediaminetetraacetic acid [51Cr-EDTA]), enteric aerobic bacterial counts, serum biochemical profiles and pathologic findings of distal ileum were measured. Diclofenac caused a marked increase in the intestinal permeability, enteric bacterial numbers and intestinal villous damage, and enteric protein and albumin loss. Combined administration of bovine colostrum reduced the increase in intestinal permeability, enteric bacterial overgrowth, protein losing enteropathy and mucosal villous damage of the small intestine induced by diclofenac. Bovine colostrum may have a beneficial effect in prevention of NSAID induced small intestinal injuries.
File Format	PDF HTM / HTML
PubMed reference number	15734716
Journal	Medline
Volume Number	14
Issue Number	1
Alternate Webpage(s)	http://apjcn.nhri.org.tw/server/APJCN/14/1/103.pdf
Alternate Webpage(s)	http://5280functionalmed.com/wp-content/uploads/2017/07/Colostrum-for-NSAID-Induced-Intestinal-Damage.pdf
Journal	Asia Pacific journal of clinical nutrition
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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