NDLI: Circulating microRNA expression profiles in ovarian cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ayaz, L. Çayan, F. Balci, S. Görür, A. Akbayir, S. Yildirim Yaroglu, H. Dogruer Unal, N. Tamer, L.
Description	Country affiliation: Turkey Author Affiliation: Ayaz L ( Department of Biochemistry, Trakya University Faculty of Pharmacy , Edirne , Turkey.)
Abstract	MicroRNA (miRNA) is an abundant class of small non-coding RNAs that act as gene regulators. Recent studies have suggested that miRNA deregulation is associated with the initiation and progression of human cancer. However, information about ovarian cancer-related miRNA is mostly limited to tissue miRNA. The aim of this study was to find specific profiles of plasma-derived miRNAs of ovarian cancer. In this present study, the expression profiles of 740 miRNAs in plasma from 18 patients and 24 healthy women subjects were evaluated using microfluidic based multiplex qRT-PCR. Our results demonstrated that expression levels of eight miRNAs were significantly upregulated in patients with ovarian cancer when compared with a control group (p < 0.05). Expression levels of four miRNAs were found significantly downregulated in patients with ovarian cancer (p < 0.05). In addition, 10 miRNAs were expressed only in the ovarian cancer group and miR-138-5p of these miRNAs is ovarian specific. In conclusion, our study suggests that detecting these ovarian cancer specific miRNAs in plasma might serve as novel non-invasive biomarkers for ovarian cancer.
File Format	HTM / HTML
ISSN	01443615
Issue Number	7
Volume Number	34
e-ISSN	13646893
Journal	Journal of Obstetrics and Gynaecology
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Micrornas Research Support, Non-u.s. Gov't Biological Markers Humans Middle Aged Discipline Obstetrics Gene Expression Profiling Blood Journal Article Case-control Studies Adult Female Aged Ovarian Neoplasms Discipline Gynaecology
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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