NDLI: Incidence, diagnosis and pathophysiology of amniotic fluid embolism.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ito, F. Akasaka, J. Koike, N. Uekuri, C. Shigemitsu, A. Kobayashi, H.
Description	Country affiliation: Japan Author Affiliation: Ito F ( Department of Obstetrics and Gynecology, Nara Medical University , Nara , Japan.)
Abstract	Amniotic fluid embolism (AFE) is a rare clinical entity, sometimes fatal. A review was conducted to describe the frequency, diagnosis and pathophysiology of AFE. The reported incidences ranged from 1.9 cases per 100,000 maternities (UK) to 6.1 per 100,000 maternities (Australia), which can vary considerably, depending on the period, region of study and the definition. Although the development of amniotic fluid-specific markers would have an impact on early diagnosis, definition of AFE based on these markers is not widely accepted. To date, immunological mechanisms, amniotic fluid-dependent anaphylactic reaction and complement activation, have been proposed as potential pathogenetic and pathophysiological mechanisms. Immune cell activation induced through complement activation may be associated with the mechanism that immediately initiates maternal death, only in susceptible individuals. This review will focus on advances in the field of AFE biology and discuss the prevalence, diagnosis and pathophysiology of AFE.
File Format	HTM / HTML
ISSN	01443615
Issue Number	7
Volume Number	34
e-ISSN	13646893
Journal	Journal of Obstetrics and Gynaecology
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Research Support, Non-u.s. Gov't Embolism, Amniotic Fluid Biological Markers Humans Discipline Obstetrics Review Epidemiology Journal Article Incidence Pregnancy Chemistry Immunology Amniotic Fluid Female Diagnosis Discipline Gynaecology
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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