| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Ruff, James S. Hugentobler, Sara A. Suchy, Amanda K. Sosa, Mirtha M. Tanner, Ruth E. Hite, Megumi E. Morrison, Linda C. Gieng, Sin H. Shigenaga, Mark K. Potts, Wayne K. |
| Description |
Author Affiliation: Ruff JS ( Department of Biology, University of Utah, Salt Lake City, UT); Hugentobler SA ( Department of Biology, University of Utah, Salt Lake City, UT); Suchy AK ( Department of Biology, University of Utah, Salt Lake City, UT); Sosa MM ( Department of Biology, University of Utah, Salt Lake City, UT); Tanner RE ( Department of Biology, University of Utah, Salt Lake City, UT); Hite ME ( Department of Biology, University of Utah, Salt Lake City, UT); Morrison LC ( Department of Biology, University of Utah, Salt Lake City, UT); Gieng SH ( Nutrition and Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, CA.); Shigenaga MK ( Nutrition and Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, CA.); Potts WK ( Department of Biology, University of Utah, Salt Lake City, UT) |
| Abstract |
BACKGROUND: Intake of added sugar has been shown to correlate with many human metabolic diseases, and rodent models have characterized numerous aspects of the resulting disease phenotypes. However, there is a controversy about whether differential health effects occur because of the consumption of either of the two common types of added sugar-high-fructose corn syrup (fructose and glucose monosaccharides; F/G) or table sugar (sucrose, a fructose and glucose disaccharide). OBJECTIVES: We tested the equivalence of sucrose- vs. F/G-containing diets on mouse (Mus musculus) longevity, reproductive success, and social dominance. METHODS: We fed wild-derived mice, outbred mice descended from wild-caught ancestors, a diet in which 25% of the calories came from either an equal ratio of F/G or an isocaloric amount of sucrose (both diets had 63% of total calories as carbohydrates). Exposure lasted 40 wk, starting at weaning (21 d of age), and then mice (104 females and 56 males) were released into organismal performances assays-seminatural enclosures where mice competed for territories, resources, and mates for 32 wk. Within enclosures all mice consumed the F/G diet. RESULTS: Females initially fed the F/G diet experienced a mortality rate 1.9 times the rate (P = 0.012) and produced 26.4% fewer offspring than females initially fed sucrose (P = 0.001). This reproductive deficiency was present before mortality differences, suggesting the F/G diet was causing physiologic performance deficits prior to mortality. No differential patterns in survival, reproduction, or social dominance were observed in males, indicating a sex-specific outcome of exposure. CONCLUSION: This study provides experimental evidence that the consumption of human-relevant levels of F/G is more deleterious than an isocaloric amount of sucrose for key organism-level health measures in female mice. |
| File Format |
HTM / HTML |
| ISSN |
00223166 |
| e-ISSN |
15416100 |
| DOI |
10.3945/jn.114.202531 |
| Journal |
Journal of Nutrition |
| Issue Number |
3 |
| Volume Number |
145 |
| Language |
English |
| Publisher |
American Society for Nutrition |
| Publisher Date |
2015-03-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Comparative Study Glucose Blood Reproduction Endpoint Determination Dietary Sucrose Weight Gain Research Support, U.s. Gov't, Non-p.h.s. Glucose Tolerance Test Adverse Effects Blood Glucose Administration & Dosage Longevity Metabolism Energy Intake Insulin Fructose Animals Diet Sex Factors Mice Discipline Nutrition |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Nutrition and Dietetics Medicine |
