NDLI: Analysis of 4-bromo-2,5-dimethoxyphenethylamine abuser's urine: identification and quantitation of urinary metabolites.

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Analysis of 4-bromo-2,5-dimethoxyphenethylamine abuser's urine: identification and quantitation of urinary metabolites.

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Analysis of 4-bromo-2,5-dimethoxyphenethylamine abuser's urine: identification and quantitation of urinary metabolites.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kanamori, Tatsuyuki Nagasawa, Kyoko Kuwayama, Kenji Tsujikawa, Kenji Iwata, Yuko T. Inoue, Hiroyuki
Description	Country affiliation: Japan Author Affiliation: Kanamori T ( National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa City, Chiba, 277-0882, Japan. kanamori@nrips.go.jp)
Abstract	The metabolites of 4-bromo-2,5-dimethoxyphenethylamine (2C-B), a psychoactive drug with hallucinogenic activity, were investigated in a urine sample from a user of 2C-B. The urine sample was deconjugated enzymatically and the metabolites were recovered by liquid-liquid extraction. The extract was analyzed by gas chromatography/mass spectrometry after derivatization, and the results were used to identify and quantitate the metabolites. 4-Bromo-2,5-dimethoxyphenylacetic acid was the most abundant metabolite of 2C-B in human urine and accounted for 73% of the total amount of detected metabolites, followed by 4-bromo-2-hydroxy-5-methoxyphenylacetic acid (13%) and 4-bromo-2,5-dimethoxyphenylethyl alcohol (4.5%). According to the literature, the main metabolites of 2C-B in rat urine are N-(4-bromo-2-methoxy-5-hydroxyphenylethyl)acetamide and N-(4-bromo-2-hydroxy-5-methoxyphenylethyl)acetamide. However, these metabolites accounted for only a small proportion of the total amount of detected metabolites in human urine, which indicates that there are significant species-specific differences in the metabolism of 2C-B. 4-Bromo-2,5-dimethoxyphenylacetic acid, which was the most abundant metabolite in human urine, is thought to be generated by deamination of 2C-B by monoamine oxidase (MAO) followed by oxidation by aldehyde dehydrogenase. Our results suggest that MAO plays a crucial role in the metabolism of 2C-B in humans.
File Format	HTM / HTML
ISSN	00221198
Issue Number	1
Volume Number	58
e-ISSN	15564029
Journal	Journal of Forensic Sciences
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Urine Humans Gas Chromatography-mass Spectrometry Discipline Forensic Sciences Forensic Toxicology Hallucinogens Journal Article Case Reports Phenylethyl Alcohol Substance-related Disorders Phenylacetates Substance Abuse Detection Diagnosis Dimethoxyphenylethylamine Analogs & Derivatives Methods
Content Type	Text
Resource Type	Case study Article
Subject	Genetics Pathology and Forensic Medicine

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