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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, Xiao-Tao Sun, Jie Chen, Song Chen, Guo-Qiang |
| Description | Country affiliation: China Author Affiliation: Li XT ( Multidisciplinary Research Center, Shantou University, Shantou 515063, Guangdong, China.) |
| Abstract | Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx), a polyester with strong mechanical properties and biocompatibility, is a member of microbial polyhydroxyalkanoates (PHA) family. Maleic anhydride was used to graft PHBHHx to form maleated PHBHHx (Ma-PHBHHx). Ma-PHBHHx with a graft degree of 0.59% was found to be more thermo-stable in comparison with PHBHHx. In vitro study demonstrated that the biocompatibility to mouse fibroblast L929 and human microvascular endothelial cells (HMEC) was improved in different degrees on Ma-PHBHHx films and scaffolds. Compared with their growth on PHBHHx, L929 and HMEC grown on Ma-PHBHHx films and scaffolds showed approximately 120% and 260% more in proliferation rates, respectively. Morphology study suggested that fine whorl-like surface structures with porosities on Ma-PHBHHx films attributed to MA grafting would be better for cell attachment and proliferation. Ma-PHBHHx scaffolds prepared by thermally induced phase separation (TIPS) with increased porosity, hydrophilicity, surface energy, and charges also were more favorable for cell growth. In addition, Ma-PHBHHx showed an accelerated degradation incubation in SBF at 37 degrees C, losing 21.4% of its original weight after 21 weeks while PHBHHx just lost 7.3%. Based on the improved biocompatibility, reasonable mechanical properties as well as accelerated biodegradation, Ma-PHBHHx has shown advantages over PHBHHx as a biomaterial for biomedical applications. |
| File Format | HTM / HTML |
| ISSN | 15493296 |
| Issue Number | 3 |
| Volume Number | 87 |
| e-ISSN | 15524965 |
| Journal | Journal of Biomedical Materials Research Part A |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2008-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cell Line Research Support, Non-u.s. Gov't Cell Proliferation Maleic Anhydrides Humans Cell Adhesion Journal Article Discipline Biomedical Engineering Tissue Scaffolds Microscopy, Confocal Chemistry Animals Surface Properties Caproates Biocompatible Materials Mice 3-hydroxybutyric Acid Porosity Tissue Engineering |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering |
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