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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Domnina, Yuliya A. Yeo, Yoon Tse, Julie Y. Bellas, Evangelia Kohane, Daniel S. |
| Description | Country affiliation: United States Author Affiliation: Domnina YA ( Division of Pediatric Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.) |
| Abstract | Application of controlled release technology to the peritoneum would allow for sustained drug levels. However, some polymeric systems either create adhesions, or rapidly exit the peritoneum; neither result is desirable. Here we have produced particles based on sphyngomyelin, a phospholipid that occurs naturally in the peritoneum, along with hyaluronic acid and the polymethacrylate Eudragit E100 (to modulate drug release). Particles with a low proportion of E100 (5% (w/w); 'high SPM') release albumin rapidly over 2 days, then more slowly; increasing the E100 to 20% (w/w; high 'E100') slowed drug release markedly. When injected in the murine peritoneum, high SPM particles were disseminated as free particles, without forming collections. There was a mild inflammatory response but no formation of adhesions. High E100 particles formed collections in all animals, with an intense inflammatory response. Even so, there were very few adhesions. These results suggest that microparticulate formulations can be produced that have acceptable drug-releasing properties and are suitable for use in the peritoneum from the standpoint of biocompatibility. |
| File Format | HTM / HTML |
| ISSN | 15493296 |
| Issue Number | 3 |
| Volume Number | 87 |
| e-ISSN | 15524965 |
| Journal | Journal of Biomedical Materials Research Part A |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2008-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Polymethacrylic Acids Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Excipients Microscopy, Electron, Scanning Hyaluronic Acid Male Administration & Dosage Drug Effects Journal Article Drug Carriers Discipline Biomedical Engineering Acrylates Microspheres Sphingomyelins Albumins Animals Biocompatible Materials Mice Pharmacokinetics Polymers Peritoneum |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering |
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