NDLI: In situ plasma fabrication of ceramic-like structure on polymeric implant with enhanced surface hardness, cytocompatibility and antibacterial capability.

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In situ plasma fabrication of ceramic-like structure on polymeric implant with enhanced surface hardness, cytocompatibility and antibacterial capability.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Jun Zhang, Wei Shi, Haigang Yang, Kun Wang, Gexia Wang, Pingli Ji, Junhui Chu, Paul K.
Description	Country affiliation: China Author Affiliation: Liu J ( Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.); Zhang W ( Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.); Shi H ( Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.); Yang K ( Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.); Wang G ( Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.); Wang P ( Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.); Ji J ( Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.); Chu PK ( Department of Physics & Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.)
Abstract	Polymeric materials are commonly found in orthopedic implants due to their unique mechanical properties and biocompatibility but the poor surface hardness and bacterial infection hamper many biomedical applications. In this study, a ceramic-like surface structure doped with silver is produced by successive plasma implantation of silicon (Si) and silver (Ag) into the polyamine 66 (PA66) substrate. Not only the surface hardness and elastic modulus are greatly enhanced due to the partial surface carbonization and the ceramic-like structure produced by the reaction between energetic Si and the carbon chain of PA66, but also the antibacterial activity is improved because of the combined effects rendered by Ag and SiC structure. Furthermore, the modified materials which exhibit good cytocompatibility upregulate bone-related genes and proteins expressions of the contacted bone mesenchymal stem cells (BMSCs). For the first time, it explores out that BMSCs osteogenesis on the antibacterial ceramic-like structure is mediated via the iNOS and nNOS signal pathways. The results reveal that in situ plasma fabrication of an antibacterial ceramic-like structure can endow PA66 with excellent surface hardness, cytocompatibility, as well as antibacterial capability.
File Format	HTM / HTML
ISSN	15493296
Issue Number	5
Journal	Journal of Biomedical Materials Research Part A
Volume Number	104
e-ISSN	15524965
Language	English
Publisher	Wiley
Publisher Date	2016-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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