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Cell shape and the presentation of adhesion ligands guide smooth muscle myogenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Douglas Sun, Michael B. Lee, Junmin Abdeen, Amr A. Kilian, Kristopher A.
Description	Author Affiliation: Zhang D ( Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.); Sun MB ( Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.); Lee J ( Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.); Abdeen AA ( Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.); Kilian KA ( Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.)
Abstract	The reliable generation of smooth muscle cells is important for a number of tissue engineering applications. Human mesenchymal stem cells (MSCs) are a promising progenitor of smooth muscle, with high expression of smooth muscle markers observed in a fraction of isolated cells, which can be increased by introduction of soluble supplements that direct differentiation. Here we demonstrate a new micropatterning technique, where peptides of different ligand affinity can be microcontact printed onto an inert background, to explore MSC differentiation to smooth muscle through controlled biochemical and biophysical cues alone. Using copper-catalyzed alkyne-azide cycloaddition (CuAAC), we patterned our surfaces with RGD peptide ligands-both a linear peptide with low integrin affinity and a cyclic version with high integrin affinity-for the culture of MSCs in shapes with various aspect ratios. At low aspect ratio, ligand affinity is a prime determinant for smooth muscle differentiation, while at high aspect ratio, ligand affinity has less of an effect. Pathway analysis reveals a role for focal adhesion turnover, Rac1, RhoA/ROCK, and calpain during smooth muscle differentiation of MSCs in response to cell shape and the affinity of the cell adhesion interface. Controlling integrin-ligand affinity at the biomaterials interface is important for mediating adhesion but may also prove useful for directing smooth muscle myogenesis. Peptide patterning enables the systematic investigation of single to multiple peptides derived from any protein, at different densities across a biomaterials surface, which has the potential to direct multiple MSC differentiation outcomes without the need for soluble supplements.
File Format	HTM / HTML
ISSN	15493296
Issue Number	5
Journal	Journal of Biomedical Materials Research Part A
Volume Number	104
e-ISSN	15524965
Language	English
Publisher	Wiley
Publisher Date	2016-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biomedical Engineering
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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