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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sun, Li Sheng, Xiugui Jiang, Jingyan Li, Xinglan Liu, Naifu Liu, Yi Zhang, Tingting Li, Dapeng Zhang, Xiaoling Wei, Ping |
| Description | Country affiliation: China Author Affiliation: Sun L ( Department of Gynecologic Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, China.); Sheng X ( Department of Gynecologic Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, China. Electronic address: jnshengxg@163.com.); Jiang J ( Department of Gynecology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.); Li X ( Department of Gynecologic Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, China.); Liu N ( Department of Gynecologic Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, China.); Liu Y ( Department of Gynecologic Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, China.); Zhang T ( Department of Gynecologic Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, China.); Li D ( Department of Gynecologic Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, China.); Zhang X ( Department of Gynecologic Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, China.); Wei P ( Department of Gynecologic Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Shandong University, Jinan, China.) |
| Abstract | OBJECTIVE: To evaluate the surgical morbidity and oncologic results after concurrent chemoradiotherapy (CCRT) followed by completion surgery for advanced cervical carcinoma. METHODS: The present retrospective analysis included 192 patients with advanced cervical cancer (stage IIB-IVA) treated with CCRT followed by surgery and 186 control patients without completion surgery. Disease-free and overall survival rates were compared. RESULTS: Of the patients who underwent surgery, 27 (14.1%) had pathologic evidence of residual disease; the local control rate with CCRT was 85.9%. After a median follow-up period of 190 months, 32 (16.7%) patients who underwent completion surgery had a recurrence compared with 59 (31.7%) of those who did not. The overall survival rate among patients who underwent extrafascial hysterectomy, extended hysterectomy, or no surgery was 72.2%, 60.1%, and 45.9% at 3 years, and 53.5%, 40.7%, and 32.2% at 5 years, respectively. CONCLUSION: Surgery after CCRT for advanced cervical cancer enabled evaluation of the pathologic response to therapy, improved local disease control in patients with a partial pathologic response, and enhanced survival. The most appropriate surgical approach was extrafascial hysterectomy with pelvic lymph node dissection. |
| File Format | HTM / HTML |
| ISSN | 00207292 |
| Issue Number | 2 |
| Volume Number | 125 |
| e-ISSN | 18793479 |
| Journal | International Journal of Gynecology & Obstetrics |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-05-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Lymph Node Excision Therapy Research Support, Non-u.s. Gov't Uterine Cervical Neoplasms Carcinoma Humans Middle Aged Discipline Obstetrics Chemoradiotherapy, Adjuvant Pelvis Journal Article Neoplasm, Residual Young Adult Adult Female Neoadjuvant Therapy Retrospective Studies Secondary Adverse Effects Prevention & Control Neoplasm Recurrence, Local Survival Rate Lymphatic Metastasis Hysterectomy Disease-free Survival Pathology Follow-up Studies Aged Discipline Gynecology Methods |
| Content Type | Text |
| Resource Type | Article |
| Subject | Obstetrics and Gynecology |
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