NDLI: Interactions between trace metals (Cu, Hg, Ni, Pb) and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Antarctic fish Trematomus bernacchii: oxidative effects on biotransformation pathway.

Please wait, while we are loading the content...

Interactions between trace metals (Cu, Hg, Ni, Pb) and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Antarctic fish Trematomus bernacchii: oxidative effects on biotransformation pathway.

Toxicological assessment of chemicals using Caenorhabditis elegans and optical oxygen respirometry.

Development and evaluation of reverse polyethylene samplers for marine phase II whole-sediment toxicity identification evaluations.

A kinetic approach to evaluate the association of acid volatile sulfide and simultaneously extracted metals in aquatic sediments.

Identifying the nonpoint source of perfluorinated compounds using a geographic information system based approach.

Dose-response regressions for algal growth and similar continuous endpoints: calculation of effective concentrations.

Trout density and health in a stream with variable water temperatures and trace element concentrations: does a cold-water source attract trout to increased metal exposure?

A fish bioassay to evaluate the toxicity associated with the ingestion of benzo[a]pyrene-contaminated benthic prey.

Global uncertainty and sensitivity analysis of a food-web bioaccumulation model.

Effects of photosystem II inhibitors and their mixture on freshwater phytoplankton succession in outdoor mesocosms

Degradation and ecotoxicity of the biomedical drug artemisinin in soil.

Microarray analysis of polychlorinated biphenyl mixture-induced changes in gene expression among Atlantic tomcod populations displaying differential sensitivity to halogenated aromatic hydrocarbons.

Characterization of ontogenetic changes in gene expression in the fathead minnow (Pimephales promelas).

Reproductive and developmental effects of transovarian exposure to o,p'-DDT in Japanese quails.

Seasonal changes of macroinvertebrate communities in a Western cape river, South Africa, receiving nonpoint-source insecticide pollution.

Application of ecosystem-scale fate and bioaccumulation models to predict fish mercury response times to changes in atmospheric deposition.

Combined experimental and theoretical study on photoinduced toxicity of an anthraquinone dye intermediate to Daphnia magna.

Estimating ecotoxicological effects of pesticide drift on nontarget arthropods in field hedgerows.

Combined effect of environmental pollutants (nickel, chlorpyrifos) and temperature on the ground beetle, Pterostichus oblongopunctatus (Coleoptera: Carabidae).

A passive sampler based on solid-phase microextraction for quantifying hydrophobic organic contaminants in sediment pore water.

Long-range transport of organic chemicals in the environment.

Effect of competing ions and complexing organic substances on the cadmium uptake by the soil bacterium Sinorhizobium meliloti.

Year: 2009 Volume: 28 Issue: 3

Year: 2009 Volume: 28 Issue: 2

Year: 2009 Volume: 28 Issue: 1

Year: 2008 Volume: 27

Year: 2007 Volume: 26

Year: 2006 Volume: 25

Year: 2004 Volume: 23

Interactions between trace metals (Cu, Hg, Ni, Pb) and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Antarctic fish Trematomus bernacchii: oxidative effects on biotransformation pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Benedetti, Maura Fattorini, Daniele Martuccio, Giacomo Nigro, Marco Regoli, Francesco
Spatial Coverage	Antarctic Regions
Description	Country affiliation: Italy Author Affiliation: Benedetti M ( Dipartimento di Biochemica, Biologia e Genetica, Università Politecnica delle Marche, Ancona, Italy.)
Abstract	Biological effects of chemical mixtures are an emerging issue when using biomarkers in field conditions, because synergistic or inhibitory interactions, cascade, and indirect mechanisms can both enhance or suppress responses to specific classes of pollutants. The Antarctic rock cod (Trematomus bernacchii) was exposed to various trace metals (Cu, Hg, Ni, and Pb) and to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dosed alone or in combination, to generate hypotheses regarding the mechanisms of action at the cellular level. Concentrations of metals significantly increased in liver of T. bernacchii without significant differences between organisms exposed only to the elements or cotreated with TCDD. The marked induction of cytochrome P450 (CYP) by TCDD was greatly suppressed by cotreatment with Cu at both catalytic and protein expression levels, whereas no significant effects were caused by coexposures with Hg, Ni, and Pb. The oxidative status was measured by integrating individual antioxidants with the total oxyradical scavenging capacity toward peroxyl radicals (ROO) and hydroxyl radicals (OH). Synergistic oxidative effects appeared in fish coexposed to Cu and TCDD, suggesting that biotransformation efficiency is down-regulated by higher levels of hydrogen peroxide, hydroxyl radicals, and/or mechanisms limiting availability of heme groups. Major oxidative perturbations also were observed in organisms coexposed to TCDD and Hg; in these organisms, however, the marked increase of glutathione content could explain the absence of oxidative inhibition of the CYP system. More limited oxidative effects were caused by Ni and Pb, and the contemporary absence of inhibitory effects on CYP would further confirm the importance of pro-oxidant mechanisms in modulating the biotransformation pathway. The overall results indicate that a wide battery of biomarkers is necessary to assess the impact of chemical mixtures in field conditions.
File Format	HTM / HTML
ISSN	07307268
Issue Number	4
Volume Number	28
e-ISSN	15528618
Journal	Environmental Toxicology and Chemistry
Language	English
Publisher	Wiley
Publisher Date	2009-04-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antarctic Regions Research Support, Non-u.s. Gov't Discipline Environmental Health Metals Hydrogen Peroxide Liver Discipline Toxicology Pharmacology Metabolism Antagonists & Inhibitors Journal Article Cytochrome P-450 Enzyme System Hydroxyl Radical Chemistry Glutathione Peroxidase Animals Catalase Biotransformation Oxidation-reduction Perciformes Discipline Chemistry Peroxides Glutathione Transferase
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Gasoline effects on biotransformation and antioxidant defenses of the freshwater fish Prochilodus lineatus.

Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15.

Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5'-ward of the cytochrome P1-450 gene.

Resolution of two forms of cytochrome P-450 from liver microsomes of rabbit treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Atrazine effects on antioxidant status and xenobiotic metabolizing enzymes after oral administration in peripubertal male rat.

Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes.

Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver.

Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6.

Radiolysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin in aqueous solutions

Interactions between trace metals (Cu, Hg, Ni, Pb) and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Antarctic fish Trematomus bernacchii: oxidative effects on biotransformation pathway.

Similar Documents

Gasoline effects on biotransformation and antioxidant defenses of the freshwater fish Prochilodus lineatus.

Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15.

Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5'-ward of the cytochrome P1-450 gene.

Resolution of two forms of cytochrome P-450 from liver microsomes of rabbit treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Atrazine effects on antioxidant status and xenobiotic metabolizing enzymes after oral administration in peripubertal male rat.

Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes.

Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver.

Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6.

Radiolysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin in aqueous solutions

Interactions between trace metals (Cu, Hg, Ni, Pb) and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Antarctic fish Trematomus bernacchii: oxidative effects on biotransformation pathway.