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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Yeong Gi Min, Se Hee Hahn, Seokyung Oh, Tae Jung Park, Kyong Soo Cho, Young Min |
| Description | Country affiliation: South Korea Author Affiliation: Kim YG ( Division of Endocrinology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea); Min SH ( Division of Endocrinology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.); Hahn S ( Department of Medicine, Seoul National University College of Medicine/Biostatistics Division of Medical Research Collaborating Center, Seoul National University Hospital, Seoul, South Korea.); Oh TJ ( Division of Endocrinology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.); Park KS ( Division of Endocrinology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.); Cho YM ( Division of Endocrinology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: ymchomd@snu.ac.kr.) |
| Abstract | AIMS: To compare the efficacy and safety of the addition of a dipeptidyl peptidase-4 (DPP-4) inhibitor or a placebo in patients with type 2 diabetes inadequately controlled with insulin. METHODS: We searched randomised controlled trials (RCTs) from MEDLINE, EMBASE, LILACS, the Cochrane Central Register of Controlled Trials and the ClinicalTrials.gov online registry. Studies of at least 12week treatment duration were eligible if they were RCTs in patients with type 2 diabetes comparing addition of a DPP-4 inhibitor to insulin therapy (INS/DPP4i) with addition of a placebo to insulin therapy (INS/PCB) and contained information on the change in glycated haemoglobin (HbA1c) from baseline. RESULTS: Of 3105 potentially relevant published articles and 206 registered trials, 9 studies were included for meta-analysis. Compared to INS/PCB, INS/DPP4i exhibited a greater reduction in HbA1c (weighted mean difference [WMD] -0.58%; 95% CI -0.70, -0.46) and fasting plasma glucose (WMD -0.59mmol/L; 95% CI -0.79, -0.40) with less daily insulin doses (WMD -1.86IU; 95% CI -3.27, -0.45) and with no difference in weight gain (WMD -0.04kg; 95% CI -0.25, 0.16). The risk of hypoglycaemia was similar between INS/DPP-4i and INS/PCB (the RR in favour of INS/PCB was 0.94; 95% CI 0.84, 1.05). CONCLUSIONS: Compared to placebo, DPP-4 inhibitors exhibit a better glycaemic control without further increasing the risk of weight gain and hypoglycaemia in patients with type 2 diabetes inadequately controlled with insulin. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Journal | Diabetes Research and Clinical Practice |
| Volume Number | 116 |
| e-ISSN | 18728227 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-06-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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