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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Buraczynska, Monika Zukowski, Pawel Ksiazek, Katarzyna Wacinski, Piotr Dragan, Michal |
| Description | Author Affiliation: Buraczynska M ( Department of Nephrology, Medical University of Lublin, Lublin, Poland. Electronic address: monika.buraczynska@umlub.pl.); Zukowski P ( Department of Nephrology, Medical University of Lublin, Lublin, Poland.); Ksiazek K ( Department of Nephrology, Medical University of Lublin, Lublin, Poland.); Wacinski P ( Department of Cardiology, Medical University of Lublin, Lublin, Poland.); Dragan M ( Department of Nephrology, Medical University of Lublin, Lublin, Poland.) |
| Abstract | OBJECTIVE: The aim of our study was to assess the association between the TLR4 Asp299Gly polymorphism and vascular complications in patients with type 2 diabetes. METHODS: We examined 1090 patients with T2DM and 716 healthy controls. All subjects were genotyped for the Asp299Gly polymorphism by polymerase chain reaction (PCR) and restriction analysis. RESULTS: The genotype frequencies of the Asp299Gly polymorphism were similar in T2DM patients and controls (p=0.512 and 0.311, respectively). The polymorphism was analyzed in subgroups of patients with macro- and microvascular complications. The distribution of genotypes was significantly different between patients with CVD and those without CVD. A significant increase of G allele frequency was observed in CVD+ patients, with odds ratio 2.06 (1.27-3.34), p=0.0035. The same effect was found when patients with diabetic retinopathy were compared with those without it (OR for G allele 2.12, 95% CI 1.43-3.12, p=0.0002). There were no statistically significant differences in genotype distribution between patients with diabetic nephropathy or neuropathy and those without these complications. CONCLUSIONS: The results of our study demonstrated that the G allele of the Asp299Gly polymorphism of the TLR4 gene is associated with increased risk of cardiovascular disease and diabetic retinopathy in type 2 diabetes patients. |
| File Format | HTM / HTML |
| ISSN | 01688227 |
| Journal | Diabetes Research and Clinical Practice |
| Volume Number | 116 |
| e-ISSN | 18728227 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-06-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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