NDLI: Glomerular and tubular damage markers in individuals with progressive albuminuria.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nauta, Ferdau L. Scheven, Lieneke Meijer, Esther Van Oeveren, Wim de Jong, Paul E. Bakker, Stephan J. L. Gansevoort, Ron T.
Description	Country affiliation: Netherlands Author Affiliation: Nauta FL ( Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.)
Abstract	BACKGROUND AND OBJECTIVES: Albuminuria is associated with risk for renal and cardiovascular disease. It is difficult to predict which persons will progress in albuminuria. This study investigated whether assessment of urinary markers associated with damage to different parts of the nephron may help identify individuals that will progress in albuminuria. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Individuals were selected from a prospective community-based cohort study with serial follow-up and defined as 'progressors' if they belonged to the quintile of participants with the most rapid annual increase in albuminuria, and reached an albuminuria ≥150 mg/d during follow-up. Patients with known renal disease or macroalbuminuria at baseline were excluded. Each progressor was matched to two control participants, based on baseline albuminuria, age, and sex. Furthermore, damage markers were measured in a separate set of healthy individuals. RESULTS: After a median follow-up of 8.6 years, 183 of 8394 participants met the criteria for progressive albuminuria. Baseline clinical characteristics were comparable between progressors and matched controls (n=366). Both had higher baseline albuminuria than the overall population. Urinary excretion of the glomerular damage marker IgG was significantly higher in progressors, whereas urinary excretion of proximal tubular damage markers and inflammatory markers was lower in these individuals compared with controls. Healthy individuals (n=109) had the lowest values for all urinary damage markers measured. CONCLUSIONS: These data suggest that albuminuria associated with markers of glomerular damage is more likely to progress, whereas albuminuria associated with markers of tubulointerstitial damage is more likely to remain stable.
File Format	HTM / HTML
ISSN	15559041
e-ISSN	1555905X
DOI	10.2215/CJN.04510512
Journal	Clinical Journal of the American Society of Nephrology
Issue Number	7
Volume Number	8
Language	English
Publisher	American Society of Nephrology
Publisher Date	2013-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Urine Research Support, Non-u.s. Gov't Inflammation Mediators Prospective Studies Kidney Tubules Biological Markers Immunoglobulin G Discipline Nephrology Albuminuria Metabolism Disease Progression Pathology Case-control Studies Time Factors Kidney Glomerulus
Content Type	Text
Resource Type	Article
Subject	Transplantation Critical Care and Intensive Care Medicine Nephrology Epidemiology

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