| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Adeli, Khosrow Higgins, Victoria Nieuwesteeg, Michelle Raizman, Joshua E. Chen, Yunqi Wong, Suzy L. Blais, David |
| Spatial Coverage |
Canada |
| Description |
Author Affiliation: Adeli K ( CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada); Higgins V ( CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada); Nieuwesteeg M ( CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada); Raizman JE ( CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada); Chen Y ( CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada); Wong SL ( Health Analysis Division, Statistics Canada, Ottawa, ON, Canada); Blais D ( Health Statistics Division, Statistics Canada, Ottawa, ON, Canada) |
| Abstract |
BACKGROUND: Defining laboratory biomarker reference values in a healthy population and understanding the fluctuations in biomarker concentrations throughout life and between sexes are critical to clinical interpretation of laboratory test results in different disease states. The Canadian Health Measures Survey (CHMS) has collected blood samples and health information from the Canadian household population. In collaboration with the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER), the data have been analyzed to determine reference value distributions and reference intervals for several endocrine and special chemistry biomarkers in pediatric, adult, and geriatric age groups. METHODS: CHMS collected data and blood samples from thousands of community participants aged 3 to 79 years. We used serum samples to measure 13 immunoassay-based special chemistry and endocrine markers. We assessed reference value distributions and, after excluding outliers, calculated age- and sex-specific reference intervals, along with corresponding 90% CIs, according to CLSI C28-A3 guidelines. RESULTS: We observed fluctuations in biomarker reference values across the pediatric, adult, and geriatric age range, with stratification required on the basis of age for all analytes. Additional sex partitions were required for apolipoprotein AI, homocysteine, ferritin, and high sensitivity C-reactive protein. CONCLUSIONS: The unique collaboration between CALIPER and CHMS has enabled, for the first time, a detailed examination of the changes in various immunochemical markers that occur in healthy individuals of different ages. The robust age- and sex-specific reference intervals established in this study provide insight into the complex biological changes that take place throughout development and aging and will contribute to improved clinical test interpretation. |
| File Format |
HTM / HTML |
| ISSN |
00099147 |
| e-ISSN |
15308561 |
| Journal |
Clinical Chemistry |
| Issue Number |
8 |
| Volume Number |
61 |
| Language |
English |
| Publisher |
American Association for Clinical Chemistry |
| Publisher Date |
2015-08-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Research Support, Non-u.s. Gov't Blood Chemical Analysis Biological Markers Child, Preschool Reference Values Discipline Laboratory Medicine Blood Reference Standards Apolipoprotein A-i Folic Acid Metabolism Endocrine System Canada Discipline Clinical Chemistry Health Surveys Adolescent Clinical Chemistry Tests Homocysteine |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Biochemistry (medical) Clinical Biochemistry |
