NDLI: Brain-targeted delivery of doxorubicin using glutathione-coated nanoparticles for brain cancers.

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Brain-targeted delivery of doxorubicin using glutathione-coated nanoparticles for brain cancers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Geldenhuys, Werner Wehrung, Daniel Groshev, Anastasia Hirani, Anjali Sutariya, Vijaykumar
Description	Author Affiliation: Geldenhuys W ( Department of Pharmaceutical Sciences, Northeast Ohio Medical University (NEOMED) , Rootstown, OH , USA and.)
Abstract	OBJECTIVES: To prepare and characterize in vitro a novel brain-targeted delivery of doxorubicin using glutathione-coated nanoparticles (NPs) for the treatment of brain cancer. METHODS: Doxorubicin-loaded NPs were prepared by the nanoprecipitation method using PLGA-COOH (dl-lactide-co-glycolide). The NPs were coated with a glutathione-PEG conjugate (PEG-GSH) in order to target delivery to the brain. The NPs were characterized via in vitro studies to determine particle size, drug release, cellular uptake, immunofluorescence study, cytotoxic assay, and in vitro blood-brain barrier (BBB) assay. RESULTS: The NPs showed a particle size suitable for BBB permeation (particle size around 200 nm). The in vitro release profile of the NPs exhibited no initial burst release and showed sustained drug release for up to 96 h. The immunofluorescence study showed the glutathione coating does not interfere with the drug release. Furthermore, in vitro BBB Transwell™ study showed significantly higher permeation of the doxorubicin-loaded NPs compared with the free doxorubicin solution through the coculture of rat brain endothelial (RBE4) and C6 astrocytoma cells (p < 0.05). CONCLUSIONS: We conclude that the initial in vitro characterization of the NPs demonstrates potential in delivering doxorubicin to cancer cells with possible future application in targeting brain cancers in vivo.
File Format	HTM / HTML
ISSN	10837450
Issue Number	4
Volume Number	20
e-ISSN	10979867
Journal	Pharmaceutical Development and Technology
Language	English
Publisher	Taylor & Francis
Publisher Date	2015-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Antibiotics, Antineoplastic Administration & Dosage Blood-brain Barrier Metabolism Doxorubicin Drug Carriers Chemistry Drug Delivery Systems Glutathione Nanoparticles Animals Pharmacokinetics Brain Neoplasms Drug Therapy Cell Line, Tumor Lactic Acid Polyethylene Glycols Polyglycolic Acid Rats Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmaceutical Science

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