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Detection of Aß Monomers and Oligomers: Early Diagnosis of Alzheimer's Disease.

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Detection of Aß Monomers and Oligomers: Early Diagnosis of Alzheimer's Disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, Yanli Liu, Lantao Hao, Yuanqiang Xu, Maotian
Description	Author Affiliation: Zhou Y ( Henan Key Laboratory Cultivation Base of Nanobiological Analytical Chemistry, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, P. R. China. zhouyanli@sqnc.edu.cn.); Liu L ( Henan Key Laboratory Cultivation Base of Nanobiological Analytical Chemistry, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, P. R. China.); Hao Y ( College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, P. R. China.); Xu M ( Henan Key Laboratory Cultivation Base of Nanobiological Analytical Chemistry, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, 476000, P. R. China.)
Abstract	Alzheimer's disease (AD), as the most common progressive neurodegenerative disorder, is pathologically characterized by deposition of extracellular plaque composed of amyloid-ß peptide (Aß). Different assembled states of Aß have been considered as both important biomarkers and drug targets for the diagnosis and therapy of AD. Recent studies demonstrate that small, diffusible Aß oligomers formed by aggregation of Aß monomers are the major toxic agents in AD. Therefore, the development of reliable assays for Aß (both monomers and oligomers) will be important for the early differential diagnosis of dementia, predicting the progression of AD, as well as monitoring the effectiveness of novel anti-Aß drugs for AD. In this review, we summarize the recent progress made in the development of techniques for detection of Aß monomers and oligomers. In particular, the principles governing the design of these sensors are classified and summarized. Moreover, the advantages and disadvantages of the assays are evaluated. This review also discusses the improvements and challenges for application of these assays in the early diagnosis of AD.
File Format	HTM / HTML
ISSN	18614728
Issue Number	6
Volume Number	11
e-ISSN	1861471X
Journal	Chemistry - An Asian Journal
Language	English
Publisher	Wiley-VCH
Publisher Date	2016-03-18
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Surface Plasmon Resonance Gold Research Support, Non-u.s. Gov't Humans Amyloid Beta-peptides Colorimetry Review Alzheimer Disease Enzyme-linked Immunosorbent Assay Journal Article Chemistry Analysis Biosensing Techniques Discipline Chemistry Diagnosis Early Diagnosis Fluorescent Dyes Metal Nanoparticles
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Biochemistry

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