NDLI: Alzheimer's disease-related amyloid-ß induces synaptotoxicity in human iPS cell-derived neurons.

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Year: 2017 Volume: 8

Year: 2016 Volume: 7

Year: 2016 Volume: 6

Year: 2015 Volume: 6

Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death.

Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p.

Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT.

Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate.

Tamoxifen reduces fat mass by boosting reactive oxygen species

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells.

A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability.

Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice.

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

Phosphorylation of the translation initiation factor eIF2 at serine 51 determines the cell fate decisions of Akt in response to oxidative stress.

Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling.

MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.

PKR downregulation prevents neurodegeneration and ß-amyloid production in a thiamine-deficient model.

Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer

Dose-dependent effects of selenite $(Se^{4+})$ on arsenite $(As^{3+})-induced$ apoptosis and differentiation in acute promyelocytic leukemia cells

Macrophage peroxisome proliferator-activated receptor Î³ deficiency delays skin wound healing through impairing apoptotic cell clearance in mice.

Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration.

NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone

The role of hypoxia-inducible factor-2 in digestive system cancers.

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma.

Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice.

DAC can restore expression of NALP1 to suppress tumor growth in colon cancer.

The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.

Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study.

Bmi1 regulates auditory hair cell survival by maintaining redox balance.

Intracellular annexin A2 regulates NF-κB signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer.

BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis.

NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT

Die for the community: an overview of programmed cell death in bacteria.

A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation.

The BH3-only protein Bad is dispensable for TNF-mediated cell death

ING1b negatively regulates HIF1 protein levels in adipose-derived stromal cells by a SUMOylation-dependent mechanism.

Interaction of differentiated human adipocytes with macrophages leads to trogocytosis and selective IL-6 secretion.

Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer

The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death.

PINK1-induced mitophagy promotes neuroprotection in Huntington's disease.

MiR-34c suppresses tumor growth and metastasis in nasopharyngeal carcinoma by targeting MET.

Loss of anchorage primarily induces non-apoptotic cell death in a human mammary epithelial cell line under atypical focal adhesion kinase signaling.

CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4.

Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications.

miR-34a regulates cell proliferation, morphology and function of newborn neurons resulting in improved behavioural outcomes.

MicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif, TAZ.

DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX.

Angelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome.

Inhibition of immunoproteasome reduces infarction volume and attenuates inflammatory reaction in a rat model of ischemic stroke.

The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.

F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.

TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium.

Induction of eosinophil apoptosis by hydrogen peroxide promotes the resolution of allergic inflammation.

Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion.

A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity.

The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma.

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death.

p21-activated kinase 1 determines stem-like phenotype and sunitinib resistance via NF-κB/IL-6 activation in renal cell carcinoma.

Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury.

Amyloid-ß reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNF from neuronal protection to death.

Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage.

Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition.

Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex.

Albumin-induced apoptosis of tubular cells is modulated by BASP1

Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.

Vibrio vulnificus VvhA induces NF-κB-dependent mitochondrial cell death via lipid raft-mediated ROS production in intestinal epithelial cells

Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells.

Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function.

Role of ion channels in regulating $Ca^{2+}$ homeostasis during the interplay between immune and cancer cells

JNK pathway activation is able to synchronize neuronal death and glial phagocytosis in Drosophila.

Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic ß-cells.

APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation.

Cellular oxidative stress response mediates radiosensitivity in Fus1-deficient mice.

Sonic hedgehog through Gli2 and Gli3 is required for the proper development of placental labyrinth.

Annexin-1 regulated by HAUSP is essential for UV-induced damage response.

In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification.

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation.

The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells.

Akt phosphorylates Prohibitin 1 to mediate its mitochondrial localization and promote proliferation of bladder cancer cells.

Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush.

p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53.

Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation.

Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny.

Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2.

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation

RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model.

LincRNA-p21 acts as a mediator of ING1b-induced apoptosis.

T-cell intracellular antigens function as tumor suppressor genes.

MiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2 signaling pathway.

DAPK2 regulates oxidative stress in cancer cells by preserving mitochondrial function.

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity.

TRPC1-mediated $Ca^{2+}$ entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy

How cell death shapes cancer.

MicroRNA-532-3p regulates mitochondrial fission through targeting apoptosis repressor with caspase recruitment domain in doxorubicin cardiotoxicity.

Reactive oxygen species and p21Waf1/Cip1 are both essential for p53-mediated senescence of head and neck cancer cells.

Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim

KLF17 empowers TGF-ß/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression.

PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion.

Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction.

BAG3 regulates formation of the SNARE complex and insulin secretion.

Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?

A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor- protein turnover.

Fgf9 inhibition of meiotic differentiation in spermatogonia is mediated by Erk-dependent activation of Nodal-Smad2/3 signaling and is antagonized by Kit Ligand.

Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma.

Life or death by NFκB, Losartan promotes survival in dy2J/dy2J mouse of MDC1A.

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.

NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways.

Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma.

T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance.

IGFBP-rP1 suppresses epithelial-mesenchymal transition and metastasis in colorectal cancer.

Autophagy is a regulator of TGF-ß1-induced fibrogenesis in primary human atrial myofibroblasts.

Homology and enzymatic requirements of microhomology-dependent alternative end joining.

Novel function of cytoplasmic p53 at the interface between mitochondria and the endoplasmic reticulum.

Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer.

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes.

Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model.

Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.

Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression.

D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH.

Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT.

Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases.

Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice.

Negative feedback loop between p66Shc and ZEB1 regulates fibrotic EMT response in lung cancer cells.

Alzheimer's disease-related amyloid-ß induces synaptotoxicity in human iPS cell-derived neurons.

Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs.

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells.

Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma.

The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila.

Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1 destabilization.

Peroxisome proliferator-activated receptorβ/δ activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation

PHRF1 promotes genome integrity by modulating non-homologous end-joining

Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis.

Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation.

GSK-3ß-dependent downregulation of Î³-taxilin and NAC merge to regulate ER stress responses.

Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury.

BCL-2 is dispensable for thrombopoiesis and platelet survival

IRE1a constitutes a negative feedback loop with BMP2 and acts as a novel mediator in modulating osteogenic differentiation.

Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice.

Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis.

Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons.

Loss of CD147 results in impaired epithelial cell differentiation and malformation of the meibomian gland.

Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo.

NOX1-induced accumulation of reactive oxygen species in abdominal fat-derived mesenchymal stromal cells impinges on long-term proliferation.

Loss of Caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis

NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair.

Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death.

Acquisition of meiotic DNA repair regulators maintain genome stability in glioblastoma

Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle.

A novel role of PRR14 in the regulation of skeletal myogenesis

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax

Peptides derived from the dependence receptor ALK are proapoptotic for ALK-positive tumors.

Wallenda regulates JNK-mediated cell death in Drosophila.

PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy.

Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice.

The synergistic interaction between the calcineurin B subunit and IFN-Î³ enhances macrophage antitumor activity.

FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients. (Part 1)

ErbB2-intronic microRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling.

Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization

Uncoupling Neogenin association with lipid rafts promotes neuronal survival and functional recovery after stroke.

Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells.

Geniposide promotes beta-cell regeneration and survival through regulating ß-catenin/TCF7L2 pathway.

Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress.

The p38 mitogen-activated protein kinase is a key regulator of myelination and remyelination in the CNS.

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.

Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.

Gankyrin drives malignant transformation of chronic liver damage-mediated fibrosis via the Rac1/JNK pathway

Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway.

Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data.

Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in ß-adrenergic signaling and enhances apoptosis.

Mcl-1 is a key regulator of the ovarian reserve.

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.

Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors.

IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.

RGD-modifided oncolytic adenovirus exhibited potent cytotoxic effect on CAR-negative bladder cancer-initiating cells.

Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner.

Stressing out the ER in aminoglycoside-induced hearing loss.

XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death.

Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53.

Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction.

miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2.

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

The nucleoprotein of influenza A virus induces p53 signaling and apoptosis via attenuation of host ubiquitin ligase RNF43.

Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.

Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication.

Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma.

Co-receptors are dispensable for tethering receptor-mediated phagocytosis of apoptotic cells.

CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis.

Cross talk between EBV and telomerase: the role of TERT and NOTCH2 in the switch of latent/lytic cycle of the virus.

Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways.

Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain

Brain death and marginal grafts in liver transplantation.

Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation

Microglia-derived IL-1ß triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells.

ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis.

1 , 25-Dihydroxyvitamin D3 and the vitamin D receptor regulates ΔNp63 levels and keratinocyte proliferation.

Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450.

Δ122p53, a mouse model of Δ133p53 , enhances the tumor-suppressor activities of an attenuated p53 mutant.

SPAG5 upregulation predicts poor prognosis in cervical cancer patients and alters sensitivity to taxol treatment via the mTOR signaling pathway.

FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients. (Part 2)

Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression.

Vibrio vulnificus VvpE inhibits mucin 2 expression by hypermethylation via lipid raft-mediated ROS signaling in intestinal epithelial cells.

Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria.

Neural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer's disease mouse model.

Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability

Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

T-cell exhaustion in the tumor microenvironment.

Tet3 mediates stable glucocorticoid-induced alterations in DNA methylation and Dnmt3a/Dkk1 expression in neural progenitors.

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells.

Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3ß-Snail pathway.

Glycation of vitronectin inhibits VEGF-induced angiogenesis by uncoupling VEGF receptor-2- vß3 integrin cross-talk.

Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer.

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions.

Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain. (Part 2)

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination.

Identification of thiostrepton as a novel therapeutic agent that targets human colon cancer stem cells.

LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer.

Disruption of cellular homeostasis induces organelle stress and triggers apoptosis like cell-death pathways in malaria parasite.

Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain

Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition.

Multiple sclerosis: getting personal with induced pluripotent stem cells.

Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents.

miR-612 negatively regulates colorectal cancer growth and metastasis by targeting AKT2.

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

First MCL-1-selective BH3 mimetics as potential therapeutics for targeted treatment of cancer

Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.

Estrogen receptor regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function.

Single-cell imaging of inflammatory caspase dimerization reveals differential recruitment to inflammasomes.

Loss of apoptosis-inducing factor critically affects MIA40 function.

FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing.

Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin.

Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility.

AIP1-mediated actin disassembly is required for postnatal germ cell migration and spermatogonial stem cell niche establishment.

2,4,5-Trimethoxyldalbergiquinol promotes osteoblastic differentiation and mineralization via the BMP and Wnt/ß-catenin pathway.

Aggregated -synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.

Targeting Mdmx to treat breast cancers with wild-type p53.

miR-205-5p-mediated downregulation of ErbB/HER receptors in breast cancer stem cells results in targeted therapy resistance.

Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer.

Intracellular oxygen determined by respiration regulates localization of Ras and prenylated proteins

Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).

Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression.

Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses.

Reciprocal positive regulation between Cx26 and PI3K/Akt pathway confers acquired gefitinib resistance in NSCLC cells via GJIC-independent induction of EMT

Interactions between muscle stem cells, mesenchymal-derived cells and immune cells in muscle homeostasis, regeneration and disease.

Genome-editing tools for stem cell biology.

Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons.

Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease.

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate.

SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.

Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival.

ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.

Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein

DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.

The potential of mesenchymal stem cells in the management of radiation enteropathy.

NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis

p53- and p73-independent activation of TIGAR expression in vivo.

Scaffolding protein Homer1a protects against NMDA-induced neuronal injury

Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: an in vivo and in vitro study.

MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer.

Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview.

Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1ß signaling.

Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.

Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition.

Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer.

MiR-26a functions oppositely in osteogenic differentiation of BMSCs and ADSCs depending on distinct activation and roles of Wnt and BMP signaling pathway.

Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification.

Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.

KAT5-mediated SOX4 acetylation orchestrates chromatin remodeling during myoblast differentiation

A novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27

Autoregulatory loop between TGF-ß1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation.

-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway.

Activation of RAR induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity.

Decreased autophagy: a major factor for cardiomyocyte death induced by ß1-adrenoceptor autoantibodies.

HMGB1 in the pathogenesis of ultraviolet-induced ocular surface inflammation.

CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells.

MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3ß expression.

DED or alive: assembly and regulation of the death effector domain complexes.

The novel protective role of P27 in MLN4924-treated gastric cancer cells

Transglutaminase 2--a novel inhibitor of adipogenesis.

Gluconeogenesis combats cancer: opening new doors in cancer biology.

Balancing functions of annexin A6 maintain equilibrium between hypertrophy and apoptosis in cardiomyocytes.

Inhibition of autophagy in EBV-positive Burkitt's lymphoma cells enhances EBV lytic genes expression and replication.

Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75(NTR) receptor-mediated activation of RhoA signaling pathways.

ER stress induces NLRP3 inflammasome activation and hepatocyte death.

Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation.

A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency.

Preventing ototoxic hearing loss by inhibiting histone deacetylases.

Radiation-induced gamma-synuclein in regards to DC function.

Absence of RIPK3 predicts necroptosis resistance in malignant melanoma.

BAC transgenic mice provide evidence that p53 expression is highly regulated in vivo.

Bone marrow-derived mesenchymal stem cells ameliorate chronic high glucose-induced ß-cell injury through modulation of autophagy.

Inhibitory PAS domain protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson's disease model.

The interplay between inflammation and metabolism in rheumatoid arthritis.

Smac mimetic-induced upregulation of interferon-ß sensitizes glioblastoma to temozolomide-induced cell death.

Drilling into RIP1 biology: what compounds are in your toolkit?

SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF- .

DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase.

Downregulation of the cancer susceptibility protein WRAP53ß in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome.

Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell lines.

IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype.

Heme-albumin: an honorary enzyme.

Nrf2: new insight in cell apoptosis.

Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation.

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma.

Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of -synuclein aggregates.

RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging.

Intrinsic hypoxia sensitivity of the cytomegalovirus promoter.

In vitro differentiation of germ cells from stem cells: a comparison between primordial germ cells and in vitro derived primordial germ cell-like cells.

Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer.

A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans.

p53 regulates the mevalonate pathway in human glioblastoma multiforme.

Bcl-2 proteins, cell migration and embryonic development: lessons from zebrafish.

TSPO as a target for treatments of diseases, including neuropathological disorders.

HOI-02 induces apoptosis and G2-M arrest in esophageal cancer mediated by ROS

Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma.

Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.

Stressing out the Hippo/YAP signaling pathway: toward a new role in Schwann cells.

Heart disease: recruitment of MEF2 activity by ß-blockers wards off cardiomyocyte death.

A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo.

Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner.

Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression

Inhibition of Notch1 signaling overcomes resistance to the death ligand Trail by specificity protein 1-dependent upregulation of death receptor 5.

EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury.

RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS.

Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.

Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells.

The RCAN1 inhibits NF-κB and suppresses lymphoma growth in mice.

Early effects of the antineoplastic agent salinomycin on mitochondrial function

Paracrine regulation in mesenchymal stem cells: the role of Rap1.

Implication of different domains of the Leishmania major metacaspase in cell death and autophagy.

Proteasomal inhibition sensitizes cervical cancer cells to mitomycin C-induced bystander effect: the role of tumor microenvironment.

Reactivation of p53 via MDM2 inhibition.

Discovering in vitro spermatogenesis stimulating factors.

Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK.

Development of a neuroprotective peptide that preserves survival pathways by preventing Kidins220/ARMS calpain processing induced by excitotoxicity.

Muscle Lim Protein (MLP)/CSRP3 at the crossroad between mechanotransduction and autophagy.

SAG-UPS regulates malignant transformation--from chronic inflammation to pro-tumorigenesis to liver cancer.

Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin.

Pur-alpha functionally interacts with FUS carrying ALS-associated mutations.

NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1.

A conserved MADS-box phosphorylation motif regulates differentiation and mitochondrial function in skeletal, cardiac, and smooth muscle cells.

Autophagy dysregulation by mutant fused in sarcoma--implications for amyotrophic lateral sclerosis.

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.

A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy.

IRAK1 mediates TLR4-induced ABCA1 downregulation and lipid accumulation in VSMCs.

Considering autophagy, ß-Catenin and E-Cadherin as innovative therapy aspects in AML.

miR-300 mediates Bmi1 function and regulates differentiation in primitive cardiac progenitors.

K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells.

DAB2IP loss confers the resistance of prostate cancer to androgen deprivation therapy through activating STAT3 and inhibiting apoptosis.

Succinate dehydrogenase/complex II activity obligatorily links mitochondrial reserve respiratory capacity to cell survival in cardiac myocytes.

Adding another piece to the retinoblastoma puzzle.

Evaluation of low doses BPA-induced perturbation of glycemia by toxicogenomics points to a primary role of pancreatic islets and to the mechanism of toxicity.

Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation.

Cracking the code of neuronal apoptosis and survival.

Transcriptional repression of cancer stem cell marker CD133 by tumor suppressor p53.

L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway

The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury.

Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.

The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival.

Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents.

Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101.

Helicobacter pylori VacA toxin causes cell death by inducing accumulation of cytoplasmic connexin 43.

Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration.

Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor.

Role of necroptosis in the pathogenesis of solid organ injury.

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

HSP70 protects human neuroblastoma cells from apoptosis and oxidative stress induced by amyloid peptide isoAsp7-Aβ(1–42)

Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation

Discrete roles of canonical and non-canonical Wnt signaling in hematopoiesis and lymphopoiesis.

Prospects of adjuvant RANKL inhibition in breast cancer?

Novel ß-carbolines inhibit Wnt/ß-catenin signaling.

Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells.

Blue light-induced retinal lesions, intraretinal vascular leakage and edema formation in the all-cone mouse retina.

Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium.

Understanding drug-cytokine synergistic toxicity.

Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4-CXCR7.

SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2.

A novel cyclic helix B peptide inhibits dendritic cell maturation during amelioration of acute kidney graft rejection through Jak-2/STAT3/SOCS1

Elevated -synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells.

In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins.

P2X7 receptor activity regulation: the role of CD44 proteoglycan GAG chains.

MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail.

Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells.

Curcumin hormesis mediates a cross-talk between autophagy and cell death.

Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.

Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells

Bcl-2 together with PI3K p110 regulates cell morphology and cell migration.

NFAT4-dependent miR-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting Mtfr1.

Macrophage migration inhibitory factor has a permissive role in concanavalin A-induced cell death of human hepatoma cells through autophagy.

Be resistant to apoptosis: a host factor from gingival fibroblasts.

Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis.

Loss of serum response factor induces microRNA-mediated apoptosis in intestinal smooth muscle cells.

Socs1 and Socs3 degrades Traf6 via polyubiquitination in LPS-induced acute necrotizing pancreatitis.

New view in cell death mode: effect of crystal size in renal epithelial cells.

Mitochondrial protection impairs BET bromodomain inhibitor-mediated cell death and provides rationale for combination therapeutic strategies.

Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway.

HIV-1 and alcohol abuse promote astrocyte inflammation: A mechanistic synergy via the cytosolic phospholipase A2 pathway.

Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8âº T-cell priming in vitro by Mer tyrosine kinase-dependent signaling.

Survive or die? c-MYC has the last word.

Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication.

Loss of STAT1 protects hair cells from ototoxicity through modulation of STAT3, c-Jun, Akt, and autophagy factors.

Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells.

Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways.

Endosulfan induces male infertility.

Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition.

TonEBP modulates the protective effect of taurine in ischemia-induced cytotoxicity in cardiomyocytes.

Myocyte-derived Tnfsf14 is a survival factor necessary for myoblast differentiation and skeletal muscle regeneration.

A minimal ING1b fragment that improves the efficacy of HDAC-based cancer cell killing.

Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines.

Histamine: a potential cytoprotective agent to improve cancer therapy?

p53-guided response to nucleostemin loss in normal versus cancer cells.

Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97.

Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.

C2238/ ANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro.

Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263

Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells.

OCGene: a database of experimentally verified ovarian cancer-related genes with precomputed regulation information.

Obesity and cancer, a case for insulin signaling.

Necrotic cone photoreceptor cell death in retinitis pigmentosa.

Year: 2014 Volume: 5

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Alzheimer's disease-related amyloid-ß induces synaptotoxicity in human iPS cell-derived neurons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nieweg, K. Andreyeva, A. Van Stegen, B. Tanriöver, G. Gottmann, K.
Description	Country affiliation: Germany Author Affiliation: Nieweg K ( 1] Institute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany [2] Institute of Pharmacology and Clinical Pharmacy, Phillips University, Marburg, Germany.); Andreyeva A ( Institute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.); van Stegen B ( Institute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.); Tanriöver G ( Institute of Pharmacology and Clinical Pharmacy, Phillips University, Marburg, Germany.); Gottmann K ( Institute of Neuro- and Sensory Physiology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.)
Abstract	Human induced pluripotent stem cell (iPSC)-derived neurons have been proposed to be a highly valuable cellular model for studying the pathomechanisms of Alzheimer's disease (AD). Studies employing patient-specific human iPSCs as models of familial and sporadic forms of AD described elevated levels of AD-related amyloid-ß (Aß). However, none of the present AD iPSC studies could recapitulate the synaptotoxic actions of Aß, which are crucial early events in a cascade that eventually leads to vast brain degeneration. Here we established highly reproducible, human iPSC-derived cortical cultures as a cellular model to study the synaptotoxic effects of Aß. We developed a highly efficient immunopurification procedure yielding immature neurons that express markers of deep layer cortical pyramidal neurons and GABAergic interneurons. Upon long-term cultivation, purified cells differentiated into mature neurons exhibiting the generation of action potentials and excitatory glutamatergic and inhibitory GABAergic synapses. Most interestingly, these iPSC-derived human neurons were strongly susceptible to the synaptotoxic actions of Aß. Application of Aß for 8 days led to a reduction in the overall FM4-64 and vGlut1 staining of vesicles in neurites, indicating a loss of vesicle clusters. A selective analysis of presynaptic vesicle clusters on dendrites did not reveal a significant change, thus suggesting that Aß impaired axonal vesicle clusters. In addition, electrophysiological patch-clamp recordings of AMPA receptor-mediated miniature EPSCs revealed an Aß-induced reduction in amplitudes, indicating an impairment of postsynaptic AMPA receptors. A loss of postsynaptic AMPA receptor clusters was confirmed by immunocytochemical stainings for GluA1. Incubation with Aß for 8 days did not result in a significant loss of neurites or cell death. In summary, we describe a highly reproducible cellular AD model based on human iPSC-derived cortical neurons that enables the mechanistic analysis of Aß-induced synaptic pathomechanisms and the development of novel therapeutic approaches.
File Format	HTM / HTML
e-ISSN	20414889
DOI	10.1038/cddis.2015.72
Journal	Cell Death and Disease
Volume Number	6
Language	English
Publisher	Nature Publishing Group
Publisher Date	2015-04-02
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Research Support, Non-u.s. Gov't Toxicity Neurons Cells, Cultured Amyloid Beta-peptides Alzheimer Disease Metabolism Drug Effects Discipline Cell Biology Pathology Tau Proteins Cell Differentiation Induced Pluripotent Stem Cells Synapses
Content Type	Text
Resource Type	Article

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